Impact of Sleeve Gastrectomy on Bone and Muscle Health in Men and Women

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the effects of sleeve gastrectomy (SG) on bone and muscle health in men and women, including premenopausal and postmenopausal women. It will compare changes in spine volumetric bone mineral density (vBMD) and muscle mass at the mid-femur between individuals who undergo SG and those who do not. Participants will be followed for three years, with assessments conducted using quantitative computed tomography (QCT) and computed tomography (CT). The study seeks to understand the potential risks associated with SG, particularly regarding bone and muscle loss.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and women aged \>18 years;
* Awaiting SG for the bariatric group or meeting the criteria for SG but not undergoing surgery for the non-surgical group.
* Menopause: defined as the absence of menses for a year and a serum follicular-stimulating hormone (FSH) \>40 UI/L.
* Women taking oral contraceptive pills or hormone replacement therapy
* Patients with type 2 diabetes.

Exclusion Criteria:

* Type 1 diabetes;
* Disease (e.g., uncontrolled thyroid disease, Malabsorptive or overt inflammatory disorder)
* Metabolic bone disease other than osteoporosis or type 2 diabetes,
* Creatinine clearance \<30 ml/min) or medication (e.g., glucocorticoids, anti-epileptic drugs, osteoporosis therapy, thiazolidinediones) affecting bone metabolism;
* Weight \>204 kg (DXA weight limit) or BMI \>60 kg/m2 (upper limit to allow for QCT examination);
* Current or planned pregnancy during follow-up; breast-feeding.

Where it's running

• Centre de recherche de l'IUCPQ
  Québec, Canada Recruiting

Study contacts

• Principal investigator: Claudia Gagnon, Dr — CHU de Québec - Université Laval
• Study coordinator: Sandrine Hegg-Deloye, PhD
• Email: sandrine.hegg-deloye@crchudequebec.ulaval.ca
• Phone: 4185254444

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Endoscopic conversion of sleeve gastrectomy to a new bypass method for reflux and obesity

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• Impact of Bariatric Surgery on Bone Health in Type 2 Diabetes Patients

  This study is testing how sleeve gastrectomy surgery affects bone health in people with type 2 diabetes compared to those who are overweight but don’t have diabetes.

  Recruiting CHU de Quebec-Universite Laval · Montreal, Quebec and 2 other locations · NCT03455868

• 15-year outcomes after sleeve gastrectomy in France

  This study looks at how people who had sleeve gastrectomy have fared over 15 years to see long-term weight changes and health effects.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07883018

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• REMS testing for osteoporosis diagnosis and fracture risk in adults compared with DXA

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  Recruiting at 2 sites BoneVue Diagnostics · Easton, Maryland and 1 other locations · NCT07876882

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.