Impact of Sequential Feeding on Circadian Rhythms and Gut Flora in Critically Ill Patients
The Effect of Sequential Feeding for Circadian Rhythm and Gut Flora Rhythm in Critically Ill Patients
This study is testing if changing the way critically ill patients are fed can help their bodies work better by syncing with their natural body clock and improving gut health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Qingdao University Academic / other |
| Locations | 1 site (Qingdao, Shan Dong Province) |
| Trial ID | NCT06083831 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how sequential feeding patterns may influence circadian rhythms and gut flora in critically ill patients. It aims to determine if adjusting feeding schedules can improve metabolic indicators and immune responses by aligning with the body's natural circadian clock. The study will monitor patients newly admitted to the ICU and compare outcomes between those receiving sequential feeding versus continuous feeding. The focus is on understanding the relationship between feeding patterns, circadian rhythms, and gut microbiome changes.
Who should consider this trial
Good fit: Ideal candidates are patients newly admitted to the ICU who can tolerate enteral feeding.
Not a fit: Patients with diabetes or gastrointestinal diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance metabolic health and immune function in critically ill patients.
How similar studies have performed: Previous studies have shown some success with sequential feeding impacting metabolic indicators and gut flora, suggesting potential for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients newly admitted to ICU were eligible for inclusion. Exclusion Criteria: * An estimated feeding time of less than 10 days in ICU; * Diabetes; * Gastrointestinal disease (gastrointestinal surgery, gastrointestinal bleeding, pancreatitis, Crohn's disease, ulcerative colitis, irritable bowel syndrome); * Inability to tolerate ≥80% of the nutrition target calories (25-30 kcal/kg/d) with enteral feeding through gastric tube; * The ability to eat orally at admission.
Where this trial is running
Qingdao, Shan Dong Province
- The affiliated hospital of qingdao university — Qingdao, Shan Dong Province, China (Recruiting)
Study contacts
- Principal investigator: bo yao, Dr. — The Affiliated Hospital of Qingdao University
- Study coordinator: bo yao, Dr.
- Email: icuyaobo@126.com
- Phone: 0532-82912220
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.