Impact of radiosurgery on hearing and balance in vestibular schwannoma patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of stereotactic radiosurgery (SRS) on patients with vestibular schwannoma, focusing on cochlear, vestibular, gustatory, and facial nerve functions. It includes both retrospective analysis of past patients treated between 2014 and 2021 and prospective follow-up of current patients. Data will be collected on demographics, clinical characteristics, and MRI features, alongside quality of life assessments through questionnaires. The aim is to evaluate the predictive value of tumor characteristics on hearing preservation and vestibular function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18 years or above
* Patients with unilateral VS treated either with SRS or MRI-based observation strategy, as proposed by the institution's skull base tumor board independently of the study
* Patients willing to take part in the study and give their informed consent

Exclusion Criteria:

* Previous surgical or radiation therapy for VS (including SRS)
* Patients diagnosed with neurofibromatosis type II
* Preexisting profound hearing loss, with a pure tone average (PTA) \>90 and word recognition score (WRS) \<10%, upon initial assessment
* Previous middle ear surgery of the affected ear
* Concurrent treatment with other experimental drugs

Where it's running

• Service d'ORL et Chirurge cervico-faciale, Hopitaux Universitaires de Genève
  Geneva, Switzerland Recruiting

Study contacts

• Study coordinator: Pascal Senn
• Email: pascal.senn@hcuge.ch
• Phone: 0223728244

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.