Impact of protein supplementation on muscle health in older men
Official title: Assessing the Impact of a Leucine Enriched Whey Protein vs Isonitrogenous Whey on Muscle Protein Synthetic Responses in the Rested and Acute Post Exercise States in Older Adults
Run by University of Nottingham · NCT06971822 · Data updated 2026-11-12
This study is testing whether a special protein supplement can help older men build and maintain muscle better than a regular protein supplement.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 65 Years and up |
| Sex | Men only |
| Enrollment | 30 (estimated) |
| Sponsor | University of Nottingham Academic / other |
| Locations | 1 site (Derby, Derbyshire) |
| Status | Recruiting |
| Started | March 14, 2025 |
| Main results expected | February 1, 2029 |
| Study ends | February 28, 2029 |
| Registry record updated | April 28, 2026 |
| Trial ID | NCT06971822 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are healthy male volunteers aged over 65 who are not suffering from significant health issues.
✕Probably not a fit
Patients with active cardiovascular, respiratory diseases, or metabolic disorders may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of leucine-enriched whey protein compared to isonitrogenous whey protein on muscle protein synthesis in older male adults, particularly focusing on their responses both at rest and after exercise. The research aims to address sarcopenia, a condition characterized by muscle loss and functional decline in the aging population, by evaluating how different protein supplements can enhance muscle health. Participants will receive protein supplementation and their muscle responses will be measured to determine the efficacy of the interventions.
Why it matters
Potential benefit: If successful, this study could lead to improved nutritional strategies for preventing muscle loss and enhancing physical function in older adults.
How similar studies have gone: Previous studies have shown positive outcomes with protein supplementation in older adults, suggesting that this approach may be effective.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Exclusion Criteria: * A BMI \<18 or \>35 kg/m2 * Active cardiovascular, cerebrovascular or respiratory disease: e.g. uncontrolled hypertension (BP \> 160/100), angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt, recent cardiac event, COPD, pulmonary hypertension or recent (6 mo) stroke * Any metabolic disease * Clotting dysfunction * A history of, or current neurological or musculoskeletal conditions (e.g. epilepsy) * Lactose intolerance * Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance
Where it's running
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Royal Derby Hospital Medical School
Derby, Derbyshire, United Kingdom Recruiting
Study contacts
- Principal investigator: Philip J Atherton — University of Nottingham
- Study coordinator: Jake Cox
- Email: mbyjc16@nottingham.ac.uk
- Phone: 07731 755075
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.