Impact of previous cesarean sections on pregnancy rates after frozen embryo transfer
To Study the Impact of a Previous Cesarean Section (CS) With / Without an Isthmocele on the Ongoing Pregnancy Rate in Single Euploid Frozen Embryo Transfer
This study looks at how having a previous cesarean section affects pregnancy rates and where embryos implant in women who are having a frozen embryo transfer.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1050 (estimated) |
| Ages | 18 Years to 42 Years |
| Sex | Female |
| Sponsor | ART Fertility Clinics LLC Academic / other |
| Locations | 1 site (Abu Dhabi) |
| Trial ID | NCT05798624 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate how a previous cesarean section (CS) affects ongoing pregnancy rates and implantation sites in women undergoing single euploid frozen embryo transfer (FET). It will analyze the differences in pregnancy outcomes between women with and without a CS, considering factors like isthmocele presence. The study will utilize ultrasound assessments between 6 and 7 weeks of pregnancy to gather data on implantation and early pregnancy symptoms. No interventions will be made, as the study focuses solely on observational data collection.
Who should consider this trial
Good fit: Ideal candidates for this study are women undergoing a single euploid frozen embryo transfer, regardless of their endometrial preparation approach.
Not a fit: Patients with known uterine anomalies, poor quality embryos, or a history of recurrent abortion may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into how previous cesarean sections influence future fertility and pregnancy outcomes, potentially guiding treatment decisions for women undergoing FET.
How similar studies have performed: Previous studies have shown mixed results regarding the impact of cesarean sections on fertility, indicating that this area is still under investigation and may yield novel insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \- All participants undergoing a single euploid FET, independent of the endometrial preparation approach Exclusion Criteria: * Intracavitary fluid during preparation for FET * Known anomaly of the uterus or the adnexae (e.g.: fibroids, polyps, hydrosalpinx, endometriosis, adenomyosis) * Embryo which was biopsied on day 7 * Poor quality embryo which was transferred (Gardner criteria: AC / BC / CB, biopsied on day 6 and CC embryos from both, day 5 and day 6 biopsies, classified as "poor" quality embryos) * History of recurrent abortion * Antiphospholipid syndrome / autoimmune diseases
Where this trial is running
Abu Dhabi
- ART Fertility Clinics LLC — Abu Dhabi, United Arab Emirates (Recruiting)
Study contacts
- Principal investigator: Barbara Lawrenz, PhD — ART Fertility Clinics LLC
- Study coordinator: Barbara Lawrenz, PhD
- Email: barbara.lawrenz@artfertilityclinics.com
- Phone: +971 2 652 8000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.