Impact of Nutrition on Cancer Immunotherapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how nutritional status affects the outcomes of immunotherapy in cancer patients. It focuses on patients who are malnourished at the time of their cancer diagnosis, as this condition can lead to increased complications and lower survival rates. The study will administer treatments including Megestrol Acetate and olanzapine, along with starch powder, to evaluate their effects on patient outcomes. Participants will be monitored for their performance status and measurable lesions as defined by standard imaging criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of cancer, malnutrition Age \>18 years Performance status ECOG of 0 or 2. Life expectancy ≥ 6 months. At least one lesion measurable as defined by standard imaging criteria for the patient's tumor type (RECIST v1.1) Patients must have normal organ and bone marrow function measured within 28 days prior to administration of study treatment Postmenopausal or evidence of non-childbearing status for women of childbearing potential Patient is willing and able to comply with the protocol for the duration of the study.

For all oral medications patients must be able to comfortably swallow capsules;

Exclusion Criteria:

* Patients unable to swallow orally administered medication and patients with Impairment of gastrointestinal (GI) function or GI disease that may significantly alter drug absorption of oral drugs History of allogenic organ, bone marrow or double umbilical cord blood transplantation.

Active or prior documented autoimmune or inflammatory disorders Uncontrolled intercurrent illness or patient considered a poor medical risk due to a serious, uncontrolled medical disorder, including but not limited to, ongoing or active infection, symptomatic congestive heart failure Currently taking medications with known risk of prolonging the QT interval or inducing Torsades de Pointes.

Where it's running

• Qingdao Central Hospital
  Qingdao, Shandong, China Recruiting

Study contacts

• Study coordinator: Keke Nie, MD
• Email: niekeke@uor.edu.cn
• Phone: 53268665078

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.