Impact of non-surgical periodontal treatment on biomarkers in periodontitis patients
Evaluation of the Effects of Nonsurgical Periodontal Treatment on Apelin and Oxidative Stress Levels in Individuals With Periodontitis
This study is testing how non-surgical gum treatment affects certain markers in the body for people with gum disease to help improve diagnosis and monitoring of their condition.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Recep Tayyip Erdogan University Training and Research Hospital Academic / other |
| Locations | 1 site (Rize) |
| Trial ID | NCT06850987 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the effects of non-surgical periodontal treatment on levels of apelin and oxidative stress in patients diagnosed with periodontitis. The research aims to identify reliable biomarkers for diagnosing and monitoring periodontal diseases by analyzing gingival crevicular fluid samples and clinical periodontal parameters. Participants will be categorized based on the 2017 Periodontal Disease Classification, focusing on those who are systemically healthy and have not undergone recent periodontal treatment. The study seeks to enhance understanding of the relationship between periodontal health and systemic conditions.
Who should consider this trial
Good fit: Ideal candidates are systemically healthy individuals diagnosed with stage 1-4 periodontitis who have at least 20 teeth and have not received periodontal treatment in the last 6 months.
Not a fit: Patients who are periodontally healthy, have systemic diseases, are pregnant or lactating, smoke, or have had recent periodontal treatment will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide new insights into biomarkers that improve the diagnosis and management of periodontitis.
How similar studies have performed: While there is limited data on the specific biomarkers being studied, previous research has shown promise in exploring the relationship between periodontal treatment and systemic health indicators.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Being systemically healthy * Not smoking * Not using anti-inflammatory drugs in the last 3 months, antibiotics and systemic corticosteroids in the last 6 months * Not being pregnant or lactating * Not having received periodontal treatment in the last 6 months * Having at least 20 teeth in the mouth * Being diagnosed with periodontitis (Stage 1-2 and Stage 3-4) by the researcher Working groups will be formed based on the 2017 Periodontal Disease Classification Exclusion Criteria: being periodontally healthy having systemic disease being pregnant and lactating smoking having periodontal treatment in the last 6 months having fewer than 20 teeth
Where this trial is running
Rize
- Recep Tayyip Erdoğan University Faculty of Dentistry — Rize, Turkey (Recruiting)
Study contacts
- Study coordinator: Hatice Yemenoglu
- Email: htcymnglu@hotmail.com
- Phone: +904642220000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.