Impact of Labor Pain Relief on Child Development

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates how maternal exposure to neuraxial labor analgesia, such as epidurals, affects the long-term neurodevelopment of children. It aims to determine if there is a correlation between the use of this pain relief method during labor and the risk of neurodevelopmental delays in offspring at 24 months of age. The study will compare outcomes between mothers who receive neuraxial analgesia and those who do not, while considering various maternal and neonatal health factors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Primiparae between 18 and 35 years of age with term single cephalic pregnancy;
2. Undergo regular prenatal examination in the study centers;
3. Preparing to deliver vaginally.

Exclusion Criteria:

1. History of psychiatric diseases (indicate those that are diagnosed before or during pregnancy by psychiatrists);
2. History of diseases involving the hypothalamic-pituitary-adrenal axis;
3. Presence of contraindications to epidural analgesia, which includes: (1) History of infectious disease of the central nervous system (poliomyelitis, cerebrospinal meningitis, encephalitis, etc.); (2) History of spinal or intra-spinal disease (trauma or surgery of spinal column, intra-spinal canal mass, etc.); (3) Systemic infection (sepsis); (4) Skin or soft tissue infection at the site of epidural puncture; (5) Coagulopathy.
4. Presence of contraindications to vaginal delivery;
5. Other reasons that are considered unsuitable for study participation.

Where it's running

• Peking University First Hospital
  Beijing, Beijing Municipality, China Recruiting
• Shenzhen Maternity and Child Healthcare Hospital
  Shenzhen, Guangdong, China Recruiting

Study contacts

• Principal investigator: Dong-Xin Wang, MD,PHD — Peking University First Hospital
• Study coordinator: Dong-Xin Wang, MD,PHD
• Email: wangdongxin@hotmail.com
• Phone: 86-13910731903

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.