Impact of hormone therapy on transgender individuals

Effects of Gender-affirming Hormone Therapy on the Psychosocial and Quality of Life of Transgender People: A Prospective Cohort Study

Observational National Taiwan University · NCT06022562

This study is testing how starting hormone therapy affects the physical and mental well-being of transgender individuals compared to those who haven't started treatment yet.

Quick facts

Study typeObservational
Enrollment300 (estimated)
Ages18 Years and up
SexAll
SponsorNational Taiwan University Academic / other
Locations1 site (Taipei)
Trial IDNCT06022562 on ClinicalTrials.gov

What this trial studies

This prospective cohort study evaluates the effects of gender-affirming hormone therapy (GAHT) on the physical, psychological, social, and quality of life aspects of transgender individuals. It will recruit 150 participants who are starting GAHT and another 150 who have not yet begun treatment. Data will be collected through questionnaires and physiological measurements, with statistical analyses to explore correlations and differences between the two groups. The findings aim to inform transgender individuals considering hormone therapy and improve care guidelines for their overall well-being.

Who should consider this trial

Good fit: Ideal candidates for this study are transgender individuals diagnosed with gender dysphoria, including trans males, trans females, and non-binary persons.

Not a fit: Patients who are not transgender or those who have already undergone hormone therapy may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide valuable insights into the benefits of hormone therapy for transgender individuals, enhancing their quality of life.

How similar studies have performed: While there have been studies on hormone therapy in transgender individuals, this prospective observational approach focusing on multiple aspects of well-being is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* transgender

Exclusion Criteria:

-

Where this trial is running

Taipei

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Gender Dysphoriadepressiongender-affirming hormone therapy
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.