Impact of high protein nutrition on critically ill trauma patients
ImpACt of Very High Protein Content Enteral nUtrition Formulas on Protein Metabolism and Residual Gastric Volume in Critically Ill MUltipLe trAuma paTiEnts
This study is testing if giving critically ill trauma patients a special high-protein diet helps them recover better than a regular protein diet.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 70 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Romanian Society for Enteral and Parenteral Nutrition Academic / other |
| Locations | 1 site (Bucharest) |
| Trial ID | NCT05647135 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effects of enteral nutrition formulas with very high protein content compared to those with normal protein content in critically ill patients with multiple trauma. It will assess energy and protein intake, gastrointestinal tolerance, and body composition changes. The study will monitor daily protein and calorie targets, as well as residual gastric volume, to determine the optimal nutritional approach for these patients. The findings could help refine nutritional strategies in the ICU setting.
Who should consider this trial
Good fit: Ideal candidates include adult patients over 18 years old who are admitted to the ICU with multiple trauma and require intubation and mechanical ventilation.
Not a fit: Patients under 18 years old, those not requiring intubation or mechanical ventilation, and individuals with contraindications to enteral feeding will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve nutritional management and outcomes for critically ill trauma patients.
How similar studies have performed: Other studies have shown positive outcomes with high protein enteral nutrition in critically ill patients, suggesting this approach may be beneficial.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (\>18 yrs) admitted to the ICU * Multiple trauma (Injury severity score \> 18) * Intubation and mechanical ventilation upon admission in ICU or during the first 24 hours of admission, for at least 48 h Exclusion Criteria: * Age \< 18 years * Pregnant women * Patients not intubated or not mechanically ventilated or receiving only non-invasive ventilation * Patients with enteral feeding contraindication 48 h after admission * Patients with recent gastrointestinal surgical intervention * Patients on chronic therapy with corticosteroids
Where this trial is running
Bucharest
- Clinical Emergency Hospital of Bucharest — Bucharest, Romania (Recruiting)
Study contacts
- Study coordinator: Ioana Grintescu, MD, PhD
- Email: ioana.grintescu@rospen.ro
- Phone: +40722329187
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.