Impact of Gastrectomy on Gut Microbiome and Cognitive Function
Effects of Total Gastrectomy or Double Track Reconstruction on Gut Microbiome and Cognitive Function in Patients With Proximal Gastric Cancer
This study is testing how different stomach surgeries for cancer affect gut bacteria and thinking skills in older patients after the operation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 45 (estimated) |
| Ages | 40 Years to 80 Years |
| Sex | All |
| Sponsor | Tongji Hospital Academic / other |
| Locations | 1 site (Wuhan, Hubei) |
| Trial ID | NCT06186089 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the effects of different surgical procedures for proximal gastric cancer, specifically total gastrectomy and double-tract reconstruction, on gut microbiota and postoperative cognitive function. It aims to understand how these surgical approaches influence gut microbiome composition and the potential link to perioperative neurocognitive disorders in elderly patients. By comparing the gut microbiota profiles and cognitive outcomes, the study seeks to shed light on the role of gastric acid and nutrient absorption in cognitive health post-surgery.
Who should consider this trial
Good fit: Ideal candidates are adults aged 40-80 with a clinical diagnosis of proximal gastric cancer who are scheduled for gastrectomy.
Not a fit: Patients with central nervous system disorders, severe immunosuppression, or those unable to communicate with physicians may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved postoperative cognitive outcomes for patients undergoing gastric surgery.
How similar studies have performed: While the role of gut microbiota in cognitive function is being explored, this specific comparison of surgical techniques in gastric cancer patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Clinical diagnosis of proximal gastric cancer and will be performed gastrectomy 2. American Society of Anesthesiologists (ASA) classification I-III 3. Aged 40-80 years 4. Perioperative consciousness Exclusion Criteria: 1. Central nervous system and psychological disorders 2. Chronic use of sedatives, antidepressants within the last year 3. Parkinson's disease 4. Severe immunosuppression 5. Severe hearing or vision impairment 6. Drug dependence; alcoholism 7. Inability to communicate with a physician
Where this trial is running
Wuhan, Hubei
- Tongji Hospital — Wuhan, Hubei, China (Recruiting)
Study contacts
- Principal investigator: Jiangjiang Bi, MD — Tongji Hospital
- Study coordinator: Jiangjiang Bi, MD
- Email: bessie8210@163.com
- Phone: 862783665431
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.