Impact of fasted exercise on heart and metabolic health
Investigating the Role of Fasted Exercise on Improving Cardiometabolic Health; a Potential Mediatory Role of Sirtuins
This study is testing whether exercising on an empty stomach is better for heart and metabolic health compared to exercising after eating, and it’s for people who want to improve their fitness and health.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Sponsor | Manchester Metropolitan University Academic / other |
| Locations | 1 site (Manchester, Greater Manchester) |
| Trial ID | NCT05742373 on ClinicalTrials.gov |
What this trial studies
This randomized control trial investigates the effects of fasted versus fed exercise on cardiometabolic health. Participants will be assigned to one of three groups: fasted exercise, fed exercise, or a control group with no exercise. Over four weeks, those in the exercise groups will engage in moderate-intensity cycling three times a week, with metabolic responses measured before and after the intervention. The study aims to assess changes in cardiovascular and metabolic disease risk factors, as well as the role of specific genes related to metabolism.
Who should consider this trial
Good fit: Ideal candidates are physically inactive adults with a BMI over 18.5 who are not pregnant and have no significant health issues.
Not a fit: Patients who are regular exercisers or have certain chronic medical conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into how fasted exercise may improve heart health and metabolic conditions.
How similar studies have performed: While the concept of fasted exercise is gaining interest, this specific approach and its potential effects on cardiometabolic health are relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or female * Non-smokers * Physically inactive (partake in no more than one exercise session per week on average) * Body mass index \>18.5 kg/m2 * Healthy as assessed by medical screening questionnaire * Prior recipient of local anaesthetic with no known adverse effects, no known hypersensitivity or no other health issue that may constrain the administration of lidocaine hydrochloride * Free from musculoskeletal injury and able to perform cycling exercise * Capacity to give informed consent Exclusion Criteria: * Regular exerciser * BMI \< 18.5 kg/m2 * Pregnant * Allergy or intolerances to test meal products/ingredients (such as wheat or dairy products). * Recent major body weight change (+/- 3 kg in the past month) * Known hypersensitivity to Lidocaine Hydrochloride * Cardiovascular disease - complete heart block or hypovolaemia * Adam's-Stokes Syndrome * Wolff-Parkinson-White Syndrome * Porphyria * Epilepsy * Myasthenia Gravis * Other chronic medical condition or diagnosis including respiratory (eg asthma), endocrine, cardiovascular, neuromuscular disorders. * Taking medications or receiving treatment that may constrain the administration of lidocaine or local anaesthesia.
Where this trial is running
Manchester, Greater Manchester
- Manchester Metropolitan University — Manchester, Greater Manchester, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Adora Yau, PhD — Manchester Metropolitan University
- Study coordinator: Adora Yau, PhD
- Email: a.yau@mmu.ac.uk
- Phone: +44(0)1612475504
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.