Impact of Exercise on Gene Expression in Stroke Patients
Effect of Exercise on Neuroplasticity-Related Gene Expression and Histone Modifications in Patients With Hemiplegia
This study is testing if a regular exercise program can help stroke survivors with paralysis improve their movement and quality of life by looking at changes in their genes.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 48 (estimated) |
| Ages | 25 Years to 70 Years |
| Sex | All |
| Sponsor | Afyonkarahisar Health Sciences University Academic / other |
| Locations | 1 site (Afyonkarahisar) |
| Trial ID | NCT06726941 on ClinicalTrials.gov |
What this trial studies
This study aims to explore how a routine exercise program influences neuroplasticity in acute stroke survivors by examining changes in histone acetylation and gene expression. It focuses on patients with hemiplegia, a common condition following ischemic stroke, and investigates the relationship between epigenetic modifications and improvements in motor function and quality of life. The research will involve systematic rehabilitation practices to maximize neuronal plasticity and enhance motor recovery through therapeutic exercise. By understanding the epigenetic effects of exercise, the study seeks to provide insights into optimizing rehabilitation strategies for stroke patients.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 25-65 who have experienced their first ischemic stroke and are seeking rehabilitation.
Not a fit: Patients with strokes caused by non-ischemic factors or those with significant neurological or systemic diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved rehabilitation strategies that enhance recovery and quality of life for stroke survivors.
How similar studies have performed: Other studies have shown promising results in using exercise to enhance neuroplasticity and recovery in stroke patients, indicating that this approach is supported by existing research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Participants who applied to Afyonkarahisar Health Sciences University Physical Therapy and Rehabilitation Clinic for rehabilitation purposes and had a stroke for the first time 2. Participants with ischemia as the etiology of stroke 3. Participants between the ages of 25-70 4. Drugs that have been used for at least 1 month and up to 6 months after a cerebrovascular accident Exclusion Criteria: 1. Participants whose stroke etiology is other than ischemia 2. Participants with clinically significant neurological disease other than stroke 3. Participants with systemic and musculoskeletal diseases that will not tolerate neurological rehabilitation and prevent them from participating
Where this trial is running
Afyonkarahisar
- Afyonkarahisar Health Sciences University — Afyonkarahisar, Turkey (Türkiye) (Recruiting)
Study contacts
- Principal investigator: Hasan Toktas, Professor — Afyonkarahisar Health Sciences University
- Study coordinator: Hasan Toktaş, Professor
- Email: hasantoktas@yahoo.com
- Phone: +905052212901
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.