Impact of exercise on coronary microvascular disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial evaluates the effects of cardiac rehabilitation combined with optimal medical therapy on patient-reported outcomes in individuals with coronary microvascular disease and non-obstructive coronary artery disease. Participants will undergo a microvascular assessment and those meeting specific criteria will be randomized to receive either optimal medical therapy alone or in combination with a structured cardiac rehabilitation program. The study aims to include approximately 204 subjects at a single center in Belgium, with a focus on personalized physical training over 36 sessions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Non obstructive CAD (diameter stenosis \<50% visual or FFR \> 0.80)
* Angina at presentation
* Evidence of microvascular dysfunction (IMR ≥ 25)

Exclusion Criteria:

* Inability to give consent
* Acute coronary syndrome (ACS)
* Severe valve disease
* Permanent AF
* History of coronary artery bypass grafting (CABG)
* Cardiomyopathies
* Intolerance to adenosine
* Hemodynamic instability
* Not able to exercise

Where it's running

• OLV Aalst
  Aalst, East-Flanders, Belgium Recruiting

Study contacts

• Study coordinator: Sofie Pardaens, PhD
• Email: sofiepardaens@coreaalst.com
• Phone: 0032 53 72 42 30

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.