Impact of Ejaculation Frequency on Semen Quality

Effect of Male Ejaculation Frequency on Semen Parameters

Observational The First Hospital of Jilin University · NCT06172504

This study looks at how different ejaculation frequencies affect semen quality in men aged 22 to 45 to better understand male fertility.

Quick facts

Study typeObservational
Enrollment1500 (estimated)
Ages22 Years to 45 Years
SexMale
SponsorThe First Hospital of Jilin University Academic / other
Drugs / interventionschemotherapy, radiation
Locations1 site (Changchun, Jilin)
Trial IDNCT06172504 on ClinicalTrials.gov

What this trial studies

This observational study aims to investigate how the frequency of ejaculation affects semen parameters in men. Participants, aged 22 to 45, who have undergone semen examination at the andrology clinic of the Reproductive Center of the First Hospital of Jilin University, will provide demographic and health information. The study will analyze semen samples based on varying ejaculation frequencies and the duration of abstinence prior to the examination, focusing on parameters such as sperm count, motility, and morphology. The findings could provide insights into male fertility and reproductive health.

Who should consider this trial

Good fit: Ideal candidates are men aged 22 to 45 with normal ejaculation function and no severe sperm abnormalities.

Not a fit: Patients with severe oligospermia or azoospermia, or those with factors adversely affecting semen parameters, may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance understanding of male fertility and inform recommendations for optimizing semen quality.

How similar studies have performed: Previous studies have explored similar relationships between ejaculation frequency and semen quality, suggesting potential for meaningful findings.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Normal ejaculation function, normal sexual life, masturbation can ejaculate
2. Male age between 22 and 45 years old.
3. According to World Health Organization standards, the semen examination time is within 48h to 7 days of abstinence.

Exclusion Criteria:

1. The man was diagnosed with extremely severe oligospermia (sperm concentration \<1 million/ml) and azoospermia.
2. Identify the factors affecting semen parameters, long-term exposure to high temperature, long-term exposure to chemicals, heavy metals, radiation and other toxic and harmful substances, orchitis/epididymitis, cryptorchidism, radiotherapy and chemotherapy treatment, and taking drugs to improve sperm within three months

Where this trial is running

Changchun, Jilin

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions SpermFertilitySemen ParametersEjaculation Frequencythe penultimate abstinence period
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.