Impact of Early Mobilization on Diaphragm Thickness in Critically Ill Children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to compare the effects of early mobilization versus routine care on diaphragm thickness in critically ill children who are mechanically ventilated. Mechanical ventilation can lead to diaphragm weakness, known as ventilator-induced diaphragm dysfunction (VIDD), which can be assessed using bedside ultrasonography. The researchers hypothesize that early mobilization will reduce the incidence of diaphragm atrophy compared to standard care. By conducting a randomized trial, they will evaluate changes in diaphragm thickness over time in the participating children.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* subjects \> 6 months and \< 12 years of age；
* subjects been intubated and mechanically ventilated for \< 24 hours at the time of screening;
* the Glasgow Coma Scale (GCS) on admission of Pediatric Intensive Care Unit (PICU) is greater than 3

Exclusion Criteria:

* cardiopulmonary arrest;
* history of diaphragmatic paralysis or neuromuscular disease;
* neuromuscular blockade;
* expectation to be liberated from ventilator in \< 24 hours
* history of mechanical ventilation in the last 6 months
* presence of tracheostomy
* high cervical spine injury
* status convulsion
* thoracic trauma when ultrasonic examination cannot be performed

Where it's running

• Children's Hospital, Fudan University
  Shanghai, China Recruiting

Study contacts

• Study coordinator: Sujuan Wang
• Email: sujuanw@163.com
• Phone: 86-13761000512

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.