Impact of Childhood Trauma on Quality of Life in Multiple Sclerosis Patients
Official title: Single-center Observational Study to Characterize Adverse Childhood Experiences (ACE) in Patients With Multiple Sclerosis and Their Impact on Quality of Life, Disease Coping Strategies, and Adherence to Disease Course-modifying Therapies
Run by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · NCT06718920 · Data updated 2026-11-12
This study looks at how childhood trauma affects the quality of life and coping strategies of people with Multiple Sclerosis to see if those early experiences impact their health and treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS Academic / other |
| Locations | 1 site (Rome, RM) |
| Status | Recruiting |
| Started | January 13, 2024 |
| Main results expected | December 2025 |
| Study ends | December 2025 |
| Registry record updated | February 26, 2025 |
| Trial ID | NCT06718920 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 years old who have been diagnosed with relapsing-remitting Multiple Sclerosis.
✕Probably not a fit
Patients who have language barriers or conditions that hinder their understanding of the questionnaires may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to evaluate how adverse childhood experiences (ACE) affect the quality of life and coping strategies of patients with Multiple Sclerosis (MS). Participants, diagnosed with relapsing-remitting MS, will complete surveys during their regular medical visits to assess the influence of childhood trauma on their disease management and treatment adherence. The study seeks to understand the relationship between early negative experiences and their long-term effects on health outcomes in MS patients.
Why it matters
Potential benefit: If successful, this study could provide insights into how childhood trauma influences the management of Multiple Sclerosis, potentially leading to improved coping strategies and quality of life for patients.
How similar studies have gone: While there is limited data on the prevalence of ACE in MS patients, previous studies have suggested a potential link between childhood trauma and health outcomes, indicating that this area is underexplored but not entirely novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age older than 18 years; * Diagnosis of relapsing-remitting multiple sclerosis according to McDonald criteria (2017 revisions) made between 2014 and 2024. * Signature of informed consent Exclusion Criteria: * Presence of language barrier * Presence of conditions that prevent or limit understanding and proper completion of questionnaires
Where it's running
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rome, Rm, Italy Recruiting
Study contacts
- Study coordinator: Massimiliano Mirabella, Neurology Associate Professor
- Email: massimiliano.mirabella@policlinicogemelli.it
- Phone: 0630155390
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.