Clinical trial Recruiting at 1 site Observational Ages 18 and up

Impact of Childhood Trauma on Quality of Life in Multiple Sclerosis Patients

Official title: Single-center Observational Study to Characterize Adverse Childhood Experiences (ACE) in Patients With Multiple Sclerosis and Their Impact on Quality of Life, Disease Coping Strategies, and Adherence to Disease Course-modifying Therapies

Run by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · NCT06718920 · Data updated 2026-11-12

This study looks at how childhood trauma affects the quality of life and coping strategies of people with Multiple Sclerosis to see if those early experiences impact their health and treatment.

More Multiple Sclerosis trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment500 (estimated)
SponsorFondazione Policlinico Universitario Agostino Gemelli IRCCS
Academic / other
Locations1 site (Rome, RM)
StatusRecruiting
StartedJanuary 13, 2024
Main results expectedDecember 2025
Study endsDecember 2025
Registry record updatedFebruary 26, 2025
Trial IDNCT06718920 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults over 18 years old who have been diagnosed with relapsing-remitting Multiple Sclerosis.

Probably not a fit

Patients who have language barriers or conditions that hinder their understanding of the questionnaires may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate how adverse childhood experiences (ACE) affect the quality of life and coping strategies of patients with Multiple Sclerosis (MS). Participants, diagnosed with relapsing-remitting MS, will complete surveys during their regular medical visits to assess the influence of childhood trauma on their disease management and treatment adherence. The study seeks to understand the relationship between early negative experiences and their long-term effects on health outcomes in MS patients.

Why it matters

Potential benefit: If successful, this study could provide insights into how childhood trauma influences the management of Multiple Sclerosis, potentially leading to improved coping strategies and quality of life for patients.

How similar studies have gone: While there is limited data on the prevalence of ACE in MS patients, previous studies have suggested a potential link between childhood trauma and health outcomes, indicating that this area is underexplored but not entirely novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age older than 18 years;
* Diagnosis of relapsing-remitting multiple sclerosis according to McDonald criteria (2017 revisions) made between 2014 and 2024.
* Signature of informed consent

Exclusion Criteria:

* Presence of language barrier
* Presence of conditions that prevent or limit understanding and proper completion of questionnaires

Where it's running

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS
    Rome, Rm, Italy
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.