Impact of cerebellum neuromodulation on social and executive functions in autism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore how neuromodulation of the cerebellum affects social and executive functions in both neurotypical young adults and those with autism. Researchers will utilize transcranial direct current stimulation to target specific cerebellar regions, hypothesizing that different areas influence distinct cognitive abilities. Participants will undergo various tasks assessing social learning and cognitive flexibility after receiving either excitatory, inhibitory, or sham stimulation. The study will also incorporate functional neuroimaging to observe changes in brain activity related to these functions.

Why it matters

Who can join: the full rules

Please note: This study takes place at American University and Georgetown University in Washington, DC. We do not have funds for travel and lodging available for this study, so participants should be local to the DC region.

Inclusion Criteria:

All participants

* Aged 18-35
* Able to provide written, informed consent
* NIH Toolbox age-adjusted Cognitive Function Composite standard score ≥ 85
* Native English speaker
* Right-handed
* Not pregnant
* Able to attend all study sessions
* Pass safety screening for MRI and neuromodulation (e.g. no metal in body, implanted devices, history of seizure, claustrophobia)

Additional INCLUSION criteria for adults with autism Either

* Prior research-reliable diagnosis of autism spectrum disorder (ASD) Or
* Meet DSM-5 criteria for ASD confirmed with ADOS-2 via research-reliable clinical assessment

Exclusion Criteria:

Neurotypical adults

* Age \<18 or \>35
* NIH Toolbox age-adjusted Cognitive Function Composite standard score \< 85
* Contraindications for MRI or neuromodulation with tDCS (e.g. metal in body, pacemaker or other implanted device, history of seizure, claustrophobia)
* Current or prior history of neurological or neurodevelopmental condition or brain injury
* Psychotropic medication
* Pregnancy

Adults with autism

* Age \<18 or \>35
* Participants with a legal authorized representative
* NIH Toolbox age-adjusted Cognitive Function Composite standard score \< 85
* Contraindications for MRI or neuromodulation with tDCS (e.g. metal in body, pacemaker or other implanted device, history of seizure, claustrophobia)
* Pregnancy

Where it's running

• American University
  Washington D.C., District of Columbia, United States Recruiting

Study contacts

• Principal investigator: Kathleen Gunthert, Ph.D. — American University
• Study coordinator: Catherine Stoodley, D.Phil.
• Email: stoodley@american.edu
• Phone: 202-476-4799

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.