Impact of anticoagulant drugs on heart and limb events after surgery in PAD patients
Effect of Anticoagulant Drug Intervention on postoperativeMajor Adverse Limb Events and Major Adverse Cardiovascular Events in Patients With Peripheral Arterial Disease
This study is testing how different blood-thinning medications affect heart and leg health in older patients with Peripheral Arterial Disease after they have surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 6000 (estimated) |
| Ages | 50 Years and up |
| Sex | All |
| Sponsor | First Affiliated Hospital of Zhejiang University Academic / other |
| Locations | 1 site (Hangzhou, None Selected) |
| Trial ID | NCT05852197 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the effects of various anticoagulant and antiplatelet drug combinations on patients with Peripheral Arterial Disease (PAD) following surgical revascularization. Patients aged 50 and older with symptomatic PAD will be monitored for Major Adverse Cardiovascular Events (MACE) and Major Adverse Limb Events (MALE) at 1, 6, and 12 months post-operation. The study aims to analyze the type, dosage, and duration of the medications administered to determine their impact on patient outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are patients aged 50 and older with symptomatic PAD who have undergone successful revascularization.
Not a fit: Patients with acute limb ischemia, significant tissue defects, or those requiring systemic anticoagulation after revascularization may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for preventing serious cardiovascular and limb-related complications in PAD patients after surgery.
How similar studies have performed: While similar studies have explored anticoagulant effects in cardiovascular contexts, this specific approach in PAD patients post-revascularization is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥50 years old 2. Patients with symptomatic PAD 3. Moderate intermittent claudication, or severe limb ischemia 4. Radiographically confirmed occlusion 5. Received a successful revascularization Exclusion Criteria: 1. Acute limb ischemia occurred within 2 weeks before revascularization; 2. Large tissue defect of any lower limb (defined as obvious ulceration/gangrene near phalangeal head); 3. After revascularization, there are clinical conditions requiring systemic anticoagulation
Where this trial is running
Hangzhou, None Selected
- First Affiliated Hospital of Zhejiang University — Hangzhou, None Selected, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.