Impact of altitude on headaches after cesarean delivery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate how altitude affects the incidence and severity of post-dural puncture headache (PDPH) in parturients undergoing spinal anesthesia for cesarean delivery. Conducted in Nepal, the study compares outcomes between high-altitude (Jumla) and low-altitude (Dharan) settings. Eligible participants will be screened based on specific criteria, and their baseline characteristics, including anxiety and chronic pain conditions, will be recorded. The diagnosis of PDPH will follow the international headache society's criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Parturient, aged more than or equal to 18 years
* American society of Anesthesiologist 2 and 3
* Scheduled for elective and non-elective (category 2 \& 3) caesarean delivery with spinal anesthesia
* Native to their resident altitude i.e., those born, raised, and have continuously lived at the same altitude, at least for the past 1 year.

Exclusion Criteria:

* Hypertensive disorder
* Cerebrovascular disease
* Mental disorder (schizophrenia and other psychotic disorders)
* Known fetal anomalies
* Contraindication to spinal anaesthesia.
* Those requiring general anaesthesia for delivery due to failed spinal anesthesia
* Major post-delivery complications (severe haemorrhage, sepsis, or ICU admission)
* Those who migrate from their resident altitude (either low to high or vice versa) within 7 days post-delivery will also be excluded.

Where it's running

• Karnali Academy of Health Sciences
  Jumla, Karnali, Nepal Recruiting
• BP Koirala Institute of Health Sciences (BPKIHS)
  Dharān, Koshi, Nepal Recruiting

Study contacts

• Study coordinator: Asish Subedi, MD
• Email: ashish.subedi@bpkihs.edu
• Phone: 9842040604

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Epidural hydroxyethyl starch to prevent post-dural puncture headache in parturients

  This study tests whether filling the epidural space with hydroxyethyl starch can help prevent post-dural puncture headaches in women who had an accidental dural puncture during epidural anesthesia for labor or cesarean delivery.

  Recruiting Peking University First Hospital · Beijing, Beijing Municipality and 3 other locations · NCT07914790

• Predicting Post-Dural Puncture Headache After Spinal Anesthesia in Cesarean Deliveries

  This study tests whether changes in optic nerve sheath diameter after spinal anesthesia can predict who will develop a post-dural puncture headache in pregnant women having an elective cesarean.

  Recruiting Ordu University · Ordu, Altinordu · NCT07729449

• Treating post-dural puncture headache with theophylline, sumatriptan, or gabapentin

  This trial will try theophylline, sumatriptan, and gabapentin to see which best relieves moderate-to-severe post-dural puncture headache in adults aged 21–50.

  Recruiting Tanta University · Tanta, El-Gharbia · NCT07515456

• Sphenopalatine ganglion block versus epidural blood patch for post-dural puncture headache

  This test compares a sphenopalatine ganglion block and an epidural blood patch to see which relieves post-dural puncture headaches better in adults whose pain hasn't improved after 24 hours of usual treatment.

  Recruiting Phase 3 University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT07354464

• Nebulized neostigmine/atropine versus nebulized lidocaine for post-dural puncture headache after cesarean delivery

  This trial tests whether inhaled (nebulized) neostigmine with atropine relieves post-dural puncture headache better than inhaled lidocaine in women who develop headache after spinal anesthesia for elective cesarean delivery.

  Recruiting Early Phase 1 Minia University · Minya · NCT06824025

• Exploring causes and treatments for postural puncture headache

  This study is trying to understand what causes post-dural puncture headaches and how treatments like epidural blood patches can help people who get them after a lumbar puncture.

  Recruiting Umeå University · Umeå, Västerbotten County · NCT06253754

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.