Imaging the blood vessels in the eyes of premature infants

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the development of retinal blood vessels in infants diagnosed with retinopathy of prematurity (ROP), a condition that can lead to childhood blindness. Using handheld Optical Coherence Tomography (OCT) with angiography, researchers will analyze how these blood vessels form around the fovea, a crucial area for vision. The study seeks to enhance understanding of vascular development in the context of ROP and preterm birth, potentially informing future interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Health care provider, knowledgeable of protocol, agrees that study personnel could contact the Parent/Legal guardian
* Parent/Legal Guardian is able and willing to consent to study participation for the infant
* Infant meets the American Association of Pediatrics eligibility of ROP screening, and is age less than 34 6/7 weeks postmenstrual age at first visit

Exclusion Criteria:

* Participant or Parent/Legal Guardian unwilling or unable to provide consent
* Infant has a health or eye condition that preclude eye examination or retinal imaging (e.g. corneal opacity such as with Peter's anomaly or cataract)
* Infant has a health condition, other than prematurity, that has a profound impact on brain development (e.g. anencephaly)

Where it's running

• Duke University
  Durham, North Carolina, United States Recruiting
• University of Pennsylvania
  Philadelphi, Pennsylvania, United States Not yet recruiting

Study contacts

• Principal investigator: Xi Chen, MD — Duke University
• Study coordinator: Xi Chen, MD
• Email: xi2.chen@duke.edu
• Phone: (919) 684-8434

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Assessing retinal health in preterm infants with advanced imaging techniques

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• Registry for infants with Retinopathy of Prematurity in Europe

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  Recruiting at 58 sites University Medicine Greifswald · Salzburg and 58 other locations · NCT04939571

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.