Identifying treatment targets for bleeding in patients with spontaneous brain hemorrhage

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to determine if a specific treatment target can be identified in patients suffering from acute, spontaneous intracerebral hemorrhage (ICH) using diagnostic cerebral Digital Subtraction Angiography (DSA). The researchers hypothesize that DSA can reveal a vessel from which contrast media leaks, indicating active bleeding. If such a target is found, it could support future trials aimed at directly addressing the bleeding to improve patient outcomes. The only intervention in this study is the additional DSA procedure performed on eligible patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of an acute spontaneous ICH based on non-contrast CT
* Time from symptom onset to anticipated start of cerebral DSA of under 3 hours
* Agreement of the treating physician to perform DSA
* Informed consent documented by signature or fulfilling the criteria for emergency consent procedures (deferral of consent)

Exclusion Criteria:

* High probability that the etiology of the bleeding is a ruptured aneurysm, an arteriovenous malformation or an amyloid angiopathy as judged by the treating physician
* Any time critical surgical or minimal invasive intervention is planned
* Evidence of an ongoing pregnancy, a negative pregnancy test is mandatory in all persons of childbearing potential
* Contraindications against the use of iodine contrast media
* Known severe kidney insufficiency (Glomerular filtration rate \< 30 ml/min)

Where it's running

• Department of Neuroradiology, University Hospital Basel
  Basel, Switzerland Recruiting

Study contacts

• Study coordinator: Alex Brehm, PhD
• Email: alex.brehm@usb.ch
• Phone: +41 61 328 79 48

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.