Identifying risk factors for extubation failure in pediatric ICU patients

The Risk Factors of Extubation Failure in Pediatric Intensive Unite Patients at Sohag University Hospitals

This study looks at what factors might make it harder for kids in the ICU to breathe on their own after being on a ventilator, to help doctors improve care for these patients.

Quick facts

• Study type: Observational
• Enrollment: 100 (estimated)
• Ages: 30 Days to 18 Years
• Sex: All
• Sponsor: Sohag University (Academic / other)
• Locations: 1 site (Sohag)
• Trial ID: NCT06557941 on ClinicalTrials.gov

What this trial studies

This observational study aims to identify risk factors associated with extubation failure in pediatric intensive care unit (PICU) patients who have undergone mechanical ventilation. It focuses on patients under 18 years who have been on mechanical ventilation for more than 12 hours and are eligible for weaning. The study will analyze various clinical parameters to determine predictors of successful extubation and to improve clinical practices in managing ventilated children. By understanding these risk factors, the study seeks to enhance patient outcomes and reduce complications associated with extubation failure.

Who should consider this trial

Good fit: Ideal candidates for this study are pediatric patients under 18 years who have been on mechanical ventilation for more than 12 hours and meet specific clinical criteria for weaning.

Not a fit: Patients who are less than 30 days old, tracheostomized, or have had unplanned extubation will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved protocols for extubation in critically ill children, potentially reducing morbidity and mortality associated with extubation failure.

How similar studies have performed: While there is limited published evidence on this specific approach, previous studies have highlighted the importance of identifying predictors for successful extubation in critically ill children, indicating a need for further investigation.

Eligibility criteria

Inclusion Criteria:

* All patient at PICU \< 18 years subjected to MV through an endotracheal tube at least \>12 hours.
* Patients eligible for weaning from MV according to the weaning criteria (Evidence for some reversal of the underlying cause following for respiratory failure, Adequate oxygenation" PaO2/FIO2 ratio ≥ 200, FIO2 ≤ 0.40, PaO2 ≥ 60, PaCO2 ≤ 60 and PEEP ≤ 5 cmH2O.", PH ≥ 7.25, Respiratory rate (RR) ≤ 45 bpm, Heart rate (HR) ≤ 140 bpm,(rapid shallow breathing index = tidal volume / RR) RSBI ≤ 8 breaths/min/ml/kg body weight, Hemodynamic stable, no or minimal vasopressor or inotropes"\[1,12\],.
* Appropriate level of consciousness, No continuous sedation infusion nor neuromuscular blocking agents, afebrile, adequate hemoglobin ≥ 7.5 g/dl and/or no evidence of hemorrhage.

Exclusion Criteria:

* Patients less than 30 days.
* Tracheostomized patients.
* Death on mv ≤ 12 hours.
* Unplanned extubation.

Where this trial is running

Sohag

• Sohag University Hospitals — Sohag, Egypt (Recruiting)

Study contacts

• Study coordinator: mariam raafat helmy, postgraduate

Conditions Extubation Failure; extubation failure; mechanical ventilation; PICU