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Clinical trial No longer in our active list Observational Ages 3 and up

Identifying risk factors for bowel dysfunction in children with Hirschsprung disease

Official title: Bowel Function and Risk Factors for Bowel Dysfunction at Preschool and Early Childhood Age in Children With Hirschsprung Disease

Run by Nanjing Children's Hospital · NCT05655845 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study is trying to find out what factors may cause bowel problems in young children with Hirschsprung disease after their surgery.

Quick facts

Study typeObservational
Ages3 Years and up
SexAll
Enrollment300 (estimated)
SponsorNanjing Children's Hospital
Academic / other
Locations1 site (Nanjing, Jiangsu)
Trial IDNCT05655845 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are preschool and early childhood children who have been clinically diagnosed with Hirschsprung disease and have completed toilet training.

Probably not a fit

Patients who have undergone redo-pull-through surgeries or have co-morbidities like Down syndrome that impair functional outcomes may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify the risk factors associated with bowel dysfunction in preschool and early childhood children diagnosed with Hirschsprung disease. The research focuses on understanding how various factors, such as the length of the aganglionic segment and surgical timing, contribute to complications like incontinence and constipation following surgical treatment. Participants will complete a bowel function score questionnaire to assess their bowel health and identify potential issues that may persist into adulthood. The findings could help improve management strategies for bowel function in affected children.

Why it matters

Potential benefit: If successful, this study could lead to better management and improved quality of life for children with Hirschsprung disease by identifying key risk factors for bowel dysfunction.

How similar studies have gone: While bowel dysfunction is a known complication of Hirschsprung disease, this study's specific focus on identifying risk factors is relatively novel and has not been extensively tested in previous research.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Clinical dignosis with Hirschsprung disease
2. completed the toilet training

Exclusion Criteria:

1. redo-pull-through,
2. Down syndrome or other co-morbidities that impaired functional outcomes

Where it's running

  • Children's Hospital of Nanjing Medical University
    Nanjing, Jiangsu, China     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov ↗ Find more trials like this →
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Bowel Dysfunction 4Hirschsprung Disease 9Incontinence 7Constipation 47Nanjing Children's Hospital 4
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.