Identifying risk factors for bowel dysfunction in children with Hirschsprung disease

Bowel Function and Risk Factors for Bowel Dysfunction at Preschool and Early Childhood Age in Children With Hirschsprung Disease

This study is trying to find out what factors may cause bowel problems in young children with Hirschsprung disease after their surgery.

Quick facts

• Study type: Observational
• Enrollment: 300 (estimated)
• Ages: 3 Years and up
• Sex: All
• Sponsor: Nanjing Children's Hospital (other)
• Locations: 1 site (Nanjing, Jiangsu)
• Trial ID: NCT05655845 on ClinicalTrials.gov

What this trial studies

This observational study aims to identify the risk factors associated with bowel dysfunction in preschool and early childhood children diagnosed with Hirschsprung disease. The research focuses on understanding how various factors, such as the length of the aganglionic segment and surgical timing, contribute to complications like incontinence and constipation following surgical treatment. Participants will complete a bowel function score questionnaire to assess their bowel health and identify potential issues that may persist into adulthood. The findings could help improve management strategies for bowel function in affected children.

Who should consider this trial

Good fit: Ideal candidates for this study are preschool and early childhood children who have been clinically diagnosed with Hirschsprung disease and have completed toilet training.

Not a fit: Patients who have undergone redo-pull-through surgeries or have co-morbidities like Down syndrome that impair functional outcomes may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to better management and improved quality of life for children with Hirschsprung disease by identifying key risk factors for bowel dysfunction.

How similar studies have performed: While bowel dysfunction is a known complication of Hirschsprung disease, this study's specific focus on identifying risk factors is relatively novel and has not been extensively tested in previous research.

Eligibility criteria

Inclusion Criteria:

1. Clinical dignosis with Hirschsprung disease
2. completed the toilet training

Exclusion Criteria:

1. redo-pull-through,
2. Down syndrome or other co-morbidities that impaired functional outcomes

Where this trial is running

Nanjing, Jiangsu

• Children's Hospital of Nanjing Medical University — Nanjing, Jiangsu, China (RECRUITING)

Study contacts

• Study coordinator: Changgui Lu, Dr

Conditions: Bowel Dysfunction, Hirschsprung Disease, Risk Factor, Incontinence, Constipation, Bowel function, associated factors