Identifying Prognostic Factors in Elderly Patients with Amyloid Heart Disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify prognostic parameters in elderly patients diagnosed with cardiac amyloidosis, particularly focusing on those over 75 years old. It seeks to understand the relationship between senile amyloid cardiomyopathy and the increasing prevalence of heart failure with preserved ejection fraction (HFpEF) in older adults. The study will involve patients from four interventional cardiology centers in the Alpine region, where their cardiac health will be evaluated to better inform treatment strategies. By analyzing the pathophysiological aspects of coronary microcirculation, the study hopes to enhance the understanding of this condition and improve patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female patient, over 75 years old
* Social Security Affiliate
* Any patient with the diagnosis of cardiac amyloidosis after etiological evaluation in one of the 4 Alpin arc interventional cardiology centers (Grenoble University Hospital, GHM Grenoble, Annecy Hospital and Chambéry Hospital).
* Non opposition to participation

Exclusion Criteria:

* Concomitant ischemic cardiopathy with revascularization following cardiac scintigraphy exploration and subsequent coronary angiography.
* Concomitant non-amyloid non-ischemic cardiopathy (valvular cardiopathy)
* Major non-cardiac illness (eg, disseminated malignancy, severe neurological dysfunction at the time of diagnosis) or social condition that may preclude participation in a research study
* Major patient protected by law (article L1121-8)
* Person deprived of liberty (Article L1121-8)

Where it's running

• Chu Grenoble Alpes
  Grenoble Cedex 9, France Recruiting

Study contacts

• Principal investigator: Charlotte CASSET — University Hospital, Grenoble
• Study coordinator: Charlotte Casset, Dr
• Email: ccasset@chu-grenoble.fr
• Phone: +33476763627

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Cardiac Amyloidosis: See if Intracardiac Thrombi are Common on CT

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• Higher pacemaker rate for people with cardiac amyloidosis

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  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07583823

• Using [64Cu]FBP8 PET/MR to find intracardiac blood clots in cardiac amyloidosis

  We'll test whether a [64Cu]FBP8 PET/MR scan can find blood clots inside the heart of people with cardiac amyloidosis who have atrial fibrillation or atrial flutter.

  Recruiting Phase 3 Brigham and Women's Hospital · Boston, Massachusetts · NCT07560306

• Chest pain screening for hidden cardiac amyloidosis

  We will test whether men over 65 who have chest pain but no coronary artery disease might have hidden cardiac amyloidosis using blood and urine tests, ECG and echocardiography, bone scintigraphy, and sometimes a heart biopsy.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT07435168

• Using advanced heart MRI to improve diagnosis and risk prediction for rare cardiomyopathies

  This project tests whether advanced cardiac MRI techniques can help diagnose and predict future risk for people with rare heart muscle diseases like Danon, Fabry, cardiac amyloidosis, Noonan syndrome, and cardiac sarcoidosis.

  Recruiting Chinese Academy of Medical Sciences, Fuwai Hospital · Beijing · NCT07336394

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.