Identifying predictors for waking up after cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to gather early neuromonitoring data from patients who have experienced out-of-hospital cardiac arrest to identify key predictors of successful wake-up. It is a substudy of the larger DANOHCA trial, focusing on the implications of sedation strategies in post-resuscitation care. The study will utilize various neuromonitoring techniques, including automated pupillometry, transcranial doppler ultrasound, and continuous EEG, to assess their prognostic value within the first six hours after resuscitation. The goal is to enhance clinical decision-making regarding sedation and improve neurological recovery outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* OHCA of presumed cardiac cause
* Sustained ROSC, defined as persistent signs of circulation and no need for chest compressions or mechanical circulatory support for 20 minutes
* Unconsciousness (GCS \<9) (patients not able to obey verbal commands) after sustained ROSC at the time of randomization

Exclusion Criteria:

* Females of childbearing potential if pregnancy is suspected (unless a negative HCG test can rule out pregnancy within the inclusion window)
* Known bleeding diathesis (medically induced coagulopathy (e.g. warfarin, NOAC, clopidogrel) does not exclude the patient)
* Suspected or confirmed acute intracranial bleeding
* Suspected or confirmed acute stroke
* Unwitnessed asystole
* Known limitations in therapy and Do Not Resuscitate-order
* Known disease making 180 days survival unlikely
* Known pre-arrest CPC 3 or 4 functional status
* \>3 hours (180 minutes) from ROSC to screening
* Systolic blood pressure \<80 mm Hg despite fluid loading/vasopressor and/or inotropic medication (If the systolic blood pressure is recovering during the inclusion window of 180 minutes the patient may be included)
* Use of intra-aortic balloon pump/axial flow device/ECMO (If the patient is weaned and the device is removed during the inclusion window of 180 minutes the patient may be included)
* Temperature on admission \<30°C
* Known allergy for dexamethasone or olanzapine
* Ongoing (within 48 h) treatment with olanzapine or dexamethasone
* Known back or hip condition that precluded the patients from being positioned with backrest from 0 to 45-degree angle
* Known or suspected Long QT Syndrome (LQTS)
* Known active fungal disease. Localized skin lesions do not exclude patients from inclusion
* Estimated body weight \<45kg

Where it's running

• Department of Intensive Care Medicine
  Aarhus N, Denmark Recruiting
• Department of Cardiology, The Heart Centre, Rigshospitalet
  Copenhagen, Denmark Recruiting

Study contacts

• Study coordinator: Christopher Torp Lohse, MD
• Email: chtorp@rm.dk
• Phone: +4526745886

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Hyperacute Neurobiomarker Kinetics in Acute Brain Injury: What Happens in Minutes After Injury

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.