Identifying pain sources in knee osteoarthritis patients awaiting surgery
Prediction Modelling of TKA Non-responders Using Clinical and Pain Sensitization Measures
University Health Network, Toronto · NCT06066684
This study is trying to find out what causes pain in people with knee osteoarthritis who are waiting for surgery, so doctors can better understand their risks for not getting better afterward.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 55 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Health Network, Toronto (other) |
| Locations | 2 sites (Hamilton, Ontario and 1 other locations) |
| Trial ID | NCT06066684 on ClinicalTrials.gov |
What this trial studies
This observational pilot trial focuses on patients with knee osteoarthritis who are on the waitlist for total knee arthroplasty. The study aims to utilize pain diagnosis tools to identify underlying pain conditions, such as myofascial pain syndrome and central sensitization, that may contribute to persistent pain after surgery. By understanding these pain sources, orthopedic surgeons can better assess the risk of patients becoming non-responders to total knee arthroplasty. The trial is conducted at two locations in Ontario, Canada.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 or older who are on the waitlist for unilateral total knee arthroplasty due to knee osteoarthritis.
Not a fit: Patients undergoing revision or non-elective surgery, or those unable to provide informed consent, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved identification of patients at risk for ongoing pain after knee surgery, allowing for better preoperative planning and management.
How similar studies have performed: While the approach of identifying pain sources in knee osteoarthritis patients is gaining attention, this specific observational study is novel and has not been extensively tested in prior research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult patients aged 18 or older * on the waitlist for TKA (unilateral) for knee osteoarthritis Exclusion Criteria: * undergoing revision or non-elective surgery * unable to provide informed consent and follow study procedures
Where this trial is running
Hamilton, Ontario and 1 other locations
- St. Joseph's Healthcare Hamilton — Hamilton, Ontario, Canada (NOT_YET_RECRUITING)
- Toronto Western Hospital — Toronto, Ontario, Canada (RECRUITING)
Study contacts
- Principal investigator: Dinesh Kumbhare, MD, PhD — UHN
- Study coordinator: OA pain research coordinator
- Email: TRI-SPARC@uhn.ca
- Phone: 416-597-3422
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Osteo Arthritis Knee, Chronic Post-operative Pain