Identifying lipid biomarkers in critically ill patients on mechanical ventilation
Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL).
This study is trying to find out if certain fats in the body can help understand how well critically ill patients on mechanical ventilation are responding to high levels of oxygen.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 110 Years |
| Sex | All |
| Sponsor | Ohio State University Academic / other |
| Locations | 1 site (Columbus, Ohio) |
| Trial ID | NCT05412810 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify and measure the levels of oxidized lipids and lipid mediators in critically ill patients undergoing mechanical ventilation with high oxygen supplementation. Patients will receive oxygen at a fraction of inspired oxygen (FiO2) of 0.5 or greater for at least 90 minutes, and two sequential mini bronchoalveolar lavages will be performed 24 hours apart. The study will utilize mass spectrometry lipid chromatography to analyze the lipid profiles and correlate them with clinical data to determine optimal oxygenation levels and their effects on inflammation and lung injury.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who require mechanical ventilation in an intensive care unit for at least 48 hours.
Not a fit: Patients who only need mechanical ventilation for procedures or have chronic respiratory failure prior to admission may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved oxygenation strategies that minimize lung injury in critically ill patients.
How similar studies have performed: While the approach of using oxidative lipidomics in this context is novel, similar studies have shown promise in understanding lipid mediators in inflammatory conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: • Adults age =\> 18 and needing Mechanical ventilation in Intensive Care unit expected atleast for 48 hours Exclusion Criteria: * 1.Mechanical ventilation, only needed for performing procedures- bronchoscopy, esophagogastroduodenoscopy, colonoscopy, or others * 2)Chronic respiratory failure prior to admission; * 3)Hemoptysis or diffuse alveolar hemorrhage * 4)Medication use such as N acetyl cysteine; aspirin, fish oil supplements. * 5)Primary team prohibits bronchoscopy for a specific clinical indication or safety;
Where this trial is running
Columbus, Ohio
- Ohio State University Medical Center — Columbus, Ohio, United States (Recruiting)
Study contacts
- Study coordinator: Sarah Karow
- Email: sarah.karow@osumc.edu
- Phone: 6142920031
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.