Identifying genetic links in movement disorders
Official title: Phenotype/Genotype Correlations in Movement Disorders
Run by National Institutes of Health Clinical Center (CC) · NCT00018889 · Data updated 2026-11-12
This study is trying to find out if there are genetic links in families with movement disorders to help understand their symptoms and identify people at risk for these conditions.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 2 Years to 100 Years |
| Sex | All |
| Enrollment | 2500 (estimated) |
| Sponsor | National Institutes of Health Clinical Center (CC) NIH |
| Locations | 1 site (Bethesda, Maryland) |
| Status | Recruiting |
| Started | October 22, 2001 |
| Registry record updated | October 23, 2026 |
| Trial ID | NCT00018889 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with suspected movement disorders and their family members.
✕Probably not a fit
Patients with movement disorders of unknown origin who do not have family members to participate may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to identify families with inherited movement disorders and evaluate their clinical manifestations using advanced technologies. It focuses on performing phenotypic and genotypic characterizations of patients and their family members to establish accurate diagnoses and investigate the underlying molecular mechanisms. The study will also explore peripheral biomarkers to better predict individuals at risk for specific neurological diseases. Participants may also be screened for eligibility in related movement disorder protocols.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnosis and understanding of genetic factors in movement disorders, potentially guiding more effective treatments.
How similar studies have gone: Other studies have shown success in identifying genetic factors in movement disorders, making this approach promising yet still expanding on existing knowledge.
Who can join: the full rules
Show full inclusion / exclusion criteria
* INCLUSION CRITERIA: * Individuals with suspected movement disorders * Family members of movement disorders patients * Ability to give informed consent or have a legally authorized representative able to give consent (for adults without consent capacity) or parent/guardian able to provide informed consent (for a child) * If unable to give informed consent, ability to give assent (for children or adults without consent capacity) * NIH Employees can participate in this study if they meet eligibility. EXCLUSION CRITERIA: * Pregnant women * Children less than 2 years of age * Employees of the Parkinson's Disease Clinic, NINDS Exclusion criteria for MRI * Presence of metal in subject s body which would make having an MRI scan unsafe, such as pacemakers, stimulators, pumps, aneurysm clips, metallic prostheses, artificial heart valves, cochlear implants or shrapnel fragments, or if subject was a welder or metal worker, since small metal fragments in the eye may be present. * Subject is uncomfortable in small closed spaces (have claustrophobia) so that they would feel uncomfortable in the MRI machine. * Unable to lie comfortably on back for up to 1 hour * Under 12 years of age There is no general exclusion for NIH employees.
Where it's running
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National Institutes of Health Clinical Center
Bethesda, Maryland, United States Recruiting
Study contacts
- Principal investigator: Debra J Ehrlich, M.D. — National Institute of Neurological Disorders and Stroke (NINDS)
- Study coordinator: Konjit Yirgashewa
- Email: konjit.yirgashewa@nih.gov
- Phone: (301) 594-5277
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Understanding movement disorders and their impact on families
This study is gathering information from people with movement disorders like Parkinson's and their families to help improve future treatments.
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Genetic analysis of movement disorders and dementia
This study is testing the genetic links between movement disorders and dementia by looking at people with these conditions, their family members, and healthy individuals to see if certain genes play a role in developing these issues.
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Database of human movement patterns
This study is collecting movement data from people of all ages to help understand and improve treatments for movement disorders.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.