Identifying genetic factors that predict pain after surgery
Development of Postoperative Pain; Clinical and Genetic Factors
This study is trying to find out if certain genes and health factors can help predict how much pain people will have after major surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 10000 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Radboud University Medical Center Academic / other |
| Locations | 1 site (Nijmegen) |
| Trial ID | NCT02383342 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify clinical and genetic factors that can predict the development of acute and chronic pain in patients undergoing elective major surgery. Over a period of 10 years, the study will prospectively include up to 10,000 patients, collecting data on demographics, medical history, and pain processing phenotypes. The goal is to establish a database and biobank that will help in understanding the genetic contributions to pain and potentially lead to personalized treatment strategies for pain management.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 80 who are scheduled for elective major surgery and can provide informed consent.
Not a fit: Patients undergoing unplanned or emergency surgeries will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better prediction and management of pain in surgical patients, improving their quality of life.
How similar studies have performed: While the involvement of genetic factors in pain is recognized, this specific approach to identifying genetic predictors in a large surgical cohort is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients: * Ages 18 - 80 years, consenting, planned surgery, able to understand and answer questionnaires. Exclusion Criteria: * Non-consent, inability to give consent, unplanned and emergency surgery.
Where this trial is running
Nijmegen
- Radboudumc — Nijmegen, Netherlands (Recruiting)
Study contacts
- Principal investigator: Barbara Franke, Prof. PhD. — Radboud University Medical Center
- Study coordinator: Rianne van Boekel, PhD.
- Email: rianne.vanboekel@radboudumc.nl
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.