Identifying genetic factors in Chinese patients with inflammatory bowel disease
Genome Wide Association (GWA) Study in Chinese Patients With Inflammatory Bowel Disease
This study is trying to find new genetic factors linked to Crohn's disease and ulcerative colitis in Chinese patients to help improve understanding and treatment of these conditions.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3600 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT01140789 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify new genetic variants associated with Crohn's disease and ulcerative colitis in Chinese patients. By conducting a genome-wide association study, the researchers will explore the genetic differences in this population, which has seen a rising incidence of inflammatory bowel disease. The study will include both patients diagnosed with IBD and matched controls without the disease to better understand the genetic underpinnings of these conditions. The findings could provide insights into the biological pathways involved in IBD and inform future treatment strategies.
Who should consider this trial
Good fit: Ideal candidates include Chinese patients aged 18 or older diagnosed with Crohn's disease or ulcerative colitis.
Not a fit: Patients who have previously been diagnosed with inflammatory bowel disease or have a first or second degree relative with IBD may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better understanding and potential new treatments for inflammatory bowel disease in Chinese patients.
How similar studies have performed: Previous genome-wide association studies in Western populations have identified numerous genes linked to IBD, but this approach in Asian populations is relatively novel and untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 or above * Informed consent given by patient or family Case group (IBD patients) Diagnosis of Crohn's disease or ulcerative colitis defined by endoscopy, radiology and histology Control group (non-IBD cases) Ethically, sex and aged-matched controls attending clinics or endoscopy for functional upper gastrointestinal diseases or screening colonoscopy. Exclusion Criteria: * No consent * Controls will be excluded if they have previously been diagnosed with IBD or if they have a first or second degree relative with IBD.
Where this trial is running
Hong Kong
- Prince of Wales Hospital — Hong Kong, Hong Kong (Recruiting)
Study contacts
- Principal investigator: Siew C NG, PhD — Chinese University of Hong Kong
- Study coordinator: Siew C NG, PhD
- Email: siewchienng@cuhk.edu.hk
- Phone: +852 3505 3509
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.