Clinical trial Recruiting at 1 site Observational Ages 20 to 90

Identifying genetic factors affecting recovery after heart surgery

Official title: Identification of Genomic Predictors of Adverse Events After Cardiac Surgery

Run by Brigham and Women's Hospital · NCT01258231 · Data updated 2026-11-12

This study is trying to find out if certain genes can help predict how well patients recover after heart surgery and if they might face complications.

Quick facts

Study typeObservational
Ages20 Years to 90 Years
SexAll
Enrollment4000 (estimated)
SponsorBrigham and Women's Hospital
Academic / other
Locations3 sites (Boston, Massachusetts and 2 other locations)
StatusRecruiting
StartedAugust 2000
Main results expectedAugust 2030
Study endsAugust 2030
Registry record updatedAugust 22, 2024
Trial IDNCT01258231 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients who are scheduled to undergo heart surgery and are willing to provide consent.

Probably not a fit

Patients currently enrolled in other drug or device trials that prevent concurrent participation may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on identifying genetic predictors of adverse events following cardiac surgery, including complications like atrial fibrillation, myocardial infarction, renal dysfunction, and heart failure. It involves analyzing blood and urine biomarkers alongside genetic data from patients undergoing heart surgery. The research is conducted at Brigham and Women's Hospital and Texas Heart Institute, aiming to enhance understanding of genetic predispositions to postoperative complications.

Why it matters

Potential benefit: If successful, this study could lead to personalized treatment strategies that minimize adverse events after cardiac surgery.

How similar studies have gone: Other studies have shown promise in identifying genetic factors related to surgical outcomes, suggesting this approach could yield valuable insights.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Undergoing heart surgery
* Willing to provide consent

Exclusion Criteria:

* Enrolled in a concurrent drug or device trial that precludes concurrent enrollment

Where it's running

  • UT Southwestern Medical Center
    Dallas, Texas, United States
    Recruiting
  • Brigham and Women's Hospital
    Boston, Massachusetts, United States
    Completed
  • Department Texas Heart Institute at St. Luke's Episcopal Hospital
    Houston, Texas, United States
    Completed

Study contacts

  • Principal investigator: Jochen D Muehlschlegel, MD MMSc, MPH — Brigham and Women's Hospital

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.