Identifying genetic factors affecting recovery after heart surgery
Official title: Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
Run by Brigham and Women's Hospital · NCT01258231 · Data updated 2026-11-12
This study is trying to find out if certain genes can help predict how well patients recover after heart surgery and if they might face complications.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 20 Years to 90 Years |
| Sex | All |
| Enrollment | 4000 (estimated) |
| Sponsor | Brigham and Women's Hospital Academic / other |
| Locations | 3 sites (Boston, Massachusetts and 2 other locations) |
| Status | Recruiting |
| Started | August 2000 |
| Main results expected | August 2030 |
| Study ends | August 2030 |
| Registry record updated | August 22, 2024 |
| Trial ID | NCT01258231 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients who are scheduled to undergo heart surgery and are willing to provide consent.
✕Probably not a fit
Patients currently enrolled in other drug or device trials that prevent concurrent participation may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on identifying genetic predictors of adverse events following cardiac surgery, including complications like atrial fibrillation, myocardial infarction, renal dysfunction, and heart failure. It involves analyzing blood and urine biomarkers alongside genetic data from patients undergoing heart surgery. The research is conducted at Brigham and Women's Hospital and Texas Heart Institute, aiming to enhance understanding of genetic predispositions to postoperative complications.
Why it matters
Potential benefit: If successful, this study could lead to personalized treatment strategies that minimize adverse events after cardiac surgery.
How similar studies have gone: Other studies have shown promise in identifying genetic factors related to surgical outcomes, suggesting this approach could yield valuable insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Undergoing heart surgery * Willing to provide consent Exclusion Criteria: * Enrolled in a concurrent drug or device trial that precludes concurrent enrollment
Where it's running
-
UT Southwestern Medical Center
Dallas, Texas, United States Recruiting -
Brigham and Women's Hospital
Boston, Massachusetts, United States Completed -
Department Texas Heart Institute at St. Luke's Episcopal Hospital
Houston, Texas, United States Completed
Study contacts
- Principal investigator: Jochen D Muehlschlegel, MD MMSc, MPH — Brigham and Women's Hospital
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.