Identifying genetic factors affecting recovery after heart surgery
Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
Brigham and Women's Hospital · NCT01258231
This study is trying to find out if certain genes can help predict how well patients recover after heart surgery and if they might face complications.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 4000 (estimated) |
| Ages | 20 Years to 90 Years |
| Sex | All |
| Sponsor | Brigham and Women's Hospital (other) |
| Locations | 3 sites (Boston, Massachusetts and 2 other locations) |
| Trial ID | NCT01258231 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on identifying genetic predictors of adverse events following cardiac surgery, including complications like atrial fibrillation, myocardial infarction, renal dysfunction, and heart failure. It involves analyzing blood and urine biomarkers alongside genetic data from patients undergoing heart surgery. The research is conducted at Brigham and Women's Hospital and Texas Heart Institute, aiming to enhance understanding of genetic predispositions to postoperative complications.
Who should consider this trial
Good fit: Ideal candidates are patients who are scheduled to undergo heart surgery and are willing to provide consent.
Not a fit: Patients currently enrolled in other drug or device trials that prevent concurrent participation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to personalized treatment strategies that minimize adverse events after cardiac surgery.
How similar studies have performed: Other studies have shown promise in identifying genetic factors related to surgical outcomes, suggesting this approach could yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Undergoing heart surgery * Willing to provide consent Exclusion Criteria: * Enrolled in a concurrent drug or device trial that precludes concurrent enrollment
Where this trial is running
Boston, Massachusetts and 2 other locations
- Brigham and Women's Hospital — Boston, Massachusetts, United States (COMPLETED)
- UT Southwestern Medical Center — Dallas, Texas, United States (RECRUITING)
- Department Texas Heart Institute at St. Luke's Episcopal Hospital — Houston, Texas, United States (COMPLETED)
Study contacts
- Principal investigator: Jochen D Muehlschlegel, MD MMSc, MPH — Brigham and Women's Hospital
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Heart, Dysfunction Postoperative, Cardiac Surgery, Genetic Predisposition to Disease, Atrial Fibrillation, Myocardial Infarction, Heart Failure