Identifying factors that predict survival in aggressive meningiomas
Official title: Analysis of Predictive Factors for Overall and Progression-free Survival After Neurosurgery for Atypical or Anaplastic Meningioma
Run by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · NCT05793034 · Data updated 2026-11-12
This study is trying to find out what factors can help predict how long patients with aggressive meningiomas will survive after surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 250 (estimated) |
| Sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS Academic / other |
| Locations | 1 site (Rome) |
| Status | Recruiting |
| Started | January 7, 2021 |
| Main results expected | January 7, 2026 |
| Study ends | January 7, 2027 |
| Registry record updated | March 13, 2025 |
| Trial ID | NCT05793034 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients who have been operated on for atypical (grade 2) or anaplastic (grade 3) meningiomas between 1999 and 2019.
✕Probably not a fit
Patients who were lost to follow-up after surgery will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to collect clinical and molecular data from patients who have undergone surgery for grade 2 or grade 3 meningiomas. The investigators will analyze various biological markers, including ICH, PCR, NGS, and methylome data, to identify predictive factors for recurrence and survival post-surgery. By focusing on these aggressive forms of meningioma, the study seeks to enhance understanding of patient outcomes and improve treatment strategies.
Why it matters
Potential benefit: If successful, this study could provide critical insights that help predict patient survival and recurrence rates, leading to more personalized treatment plans.
How similar studies have gone: While this approach is focused on aggressive meningiomas, similar studies in other tumor types have shown success in identifying predictive factors for patient outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patient operated for atypical (grade 2) meningioma; or 2. Patient operated for anaplastic (grade 3) meningioma; 3. Timeframe for surgery, 1999-2019 Exclusion criteria 1\) Patient lost at follow-up
Where it's running
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Fondazione Policlinico Universitario A. Gemelli IRCCS
Rome, Italy Recruiting
Study contacts
- Study coordinator: Alessandro Olivi, MD
- Email: alessandro.olivi@policlinicogemelli.it
- Phone: +39 06 3015 4120
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.