Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Identifying factors that predict survival in aggressive meningiomas

Official title: Analysis of Predictive Factors for Overall and Progression-free Survival After Neurosurgery for Atypical or Anaplastic Meningioma

Run by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · NCT05793034 · Data updated 2026-11-12

This study is trying to find out what factors can help predict how long patients with aggressive meningiomas will survive after surgery.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment250 (estimated)
SponsorFondazione Policlinico Universitario Agostino Gemelli IRCCS
Academic / other
Locations1 site (Rome)
StatusRecruiting
StartedJanuary 7, 2021
Main results expectedJanuary 7, 2026
Study endsJanuary 7, 2027
Registry record updatedMarch 13, 2025
Trial IDNCT05793034 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are patients who have been operated on for atypical (grade 2) or anaplastic (grade 3) meningiomas between 1999 and 2019.

Probably not a fit

Patients who were lost to follow-up after surgery will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to collect clinical and molecular data from patients who have undergone surgery for grade 2 or grade 3 meningiomas. The investigators will analyze various biological markers, including ICH, PCR, NGS, and methylome data, to identify predictive factors for recurrence and survival post-surgery. By focusing on these aggressive forms of meningioma, the study seeks to enhance understanding of patient outcomes and improve treatment strategies.

Why it matters

Potential benefit: If successful, this study could provide critical insights that help predict patient survival and recurrence rates, leading to more personalized treatment plans.

How similar studies have gone: While this approach is focused on aggressive meningiomas, similar studies in other tumor types have shown success in identifying predictive factors for patient outcomes.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Patient operated for atypical (grade 2) meningioma; or
2. Patient operated for anaplastic (grade 3) meningioma;
3. Timeframe for surgery, 1999-2019

Exclusion criteria

1\) Patient lost at follow-up

Where it's running

  • Fondazione Policlinico Universitario A. Gemelli IRCCS
    Rome, Italy
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.