Identifying factors that predict blood transfusion needs during liver transplantation
Predictive Factors for Massive Transfusion During Liver Transplantation: an Observational Study
This study looks at what factors might cause patients to need more blood transfusions during liver transplants to help improve care and outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS Academic / other |
| Locations | 2 sites (Rome and 1 other locations) |
| Trial ID | NCT05763446 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the predictive factors for massive transfusion requirements during liver transplantation (LT). It focuses on understanding how increased transfusion needs impact patient prognosis and identifies risk factors associated with high transfusion requirements. The study will analyze data from patients undergoing LT, particularly looking at pre-transplant factors such as portal hypertension and coagulation defects that may contribute to intraoperative bleeding. By clarifying these factors, the study seeks to improve management strategies during LT.
Who should consider this trial
Good fit: Ideal candidates for this study are patients scheduled to undergo liver transplantation.
Not a fit: Patients under 18 years old or those undergoing retransplantation within 30 days will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance patient outcomes by optimizing blood management during liver transplantation.
How similar studies have performed: Other studies have explored transfusion requirements in liver transplantation, indicating that understanding these factors can lead to improved surgical outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing liver transplantation Exclusion Criteria: * Age \<18 years * Retransplantation within 30 days * Combined kidney-liver transplantation
Where this trial is running
Rome and 1 other locations
- Fondazione Policlinico Universitario A. Gemelli IRCCS — Rome, Italy (Recruiting)
- UOC Anestesia delle Chirurgie Generali e dei Trapianti, Fondazione Policlinico Universitario A. Gemelli IRCCS — Rome, Italy (Recruiting)
Study contacts
- Principal investigator: Paola Aceto, MD — Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
- Study coordinator: Paola Aceto, MD
- Email: paola.aceto@policlinicogemelli.it
- Phone: +390630154507
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.