Identifying early predictors of liver survival in biliary atresia patients after surgery
Early Predictors for the Short Term Native Liver Survival in Patients With Biliary Atresia After Kasai Procedure
This study is trying to find out which early signs can help doctors predict how well the liver will survive after surgery in kids with biliary atresia.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 6 Months to 6 Years |
| Sex | All |
| Sponsor | Nanjing Children's Hospital Academic / other |
| Locations | 1 site (Nanjing) |
| Trial ID | NCT05909033 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate and identify preoperative and early postoperative factors that influence native liver survival (NLS) in patients with biliary atresia who have undergone the Kasai procedure. Biliary atresia is a serious condition that often leads to the need for liver transplants, and understanding early predictors of NLS could help in making timely decisions regarding transplant needs. The study will analyze various factors, including age at surgery and biochemical markers, to establish their correlation with liver survival outcomes. By focusing on early predictors, the research seeks to improve patient counseling and management strategies.
Who should consider this trial
Good fit: Ideal candidates for this study are infants diagnosed with biliary atresia who have undergone the Kasai procedure and have completed at least six months of follow-up.
Not a fit: Patients who have not undergone the Kasai procedure or those with severe complications leading to death may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early identification of biliary atresia patients at risk for liver failure, allowing for timely interventions.
How similar studies have performed: While many studies have explored factors affecting liver survival in biliary atresia, this specific focus on early predictors post-Kasai procedure is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Biliary Atresia(BA) patients performed with Kasai Procedure patients completed the follow-up\>6 months Exclusion Criteria: BA patients without KP patients lost of follow-up BA patients with other severe complications lead to death
Where this trial is running
Nanjing
- Children's Hospital of Nanjing Medical University — Nanjing, China (Recruiting)
Study contacts
- Principal investigator: Weibing Tang, Dr — Children's Hospital of Nanjing Medical University
- Study coordinator: Changgui Lu, Dr
- Email: luchanggui1984@163.com
- Phone: 13770848448
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.