Identifying causes of unexplained bleeding

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify specific biological patterns in patients experiencing unexplained bleeding disorders. It involves drawing blood from participants to evaluate their hemostatic profiles, which will then be compared to a control group of healthy individuals. The study will follow both patients and controls for a duration of three years to better understand the mechanisms behind the bleeding disorders.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Man with ISTH BAT\>3. If the calculated score includes a surgical bleeding, then two other items of the score should be \>0
* Woman with ISTH BAT \>5 points. If the calculated score includes a surgical or a postpartum bleeding, then two other items of the score should be \>0

Exclusion Criteria:

* Ongoing pregnancy
* Intake of antithrombotic treatment or non-steroidal anti-inflammatory drugs for least 10 days at time of blood collection
* Intake of antifibrinolytic or blood product administration (factor concentrate, frozen fresh plasma, prothrombin complex concentrate) for least 14 days before blood collection
* Active cancer (defined as cancer diagnosis within the last five years or treatment within the two last years before study inclusion)
* Active autoimmune disease
* Active chronic inflammatory disease
* Severe liver disease (cirrhosis \> Child A)
* Renal insufficiency stage 3
* Active or recent infection (within the last 30 days)
* Recent hospitalization (\<3 months)
* Recent surgery (\<3 months)
* Recent trauma requiring medical intervention (\<3 months)

Where it's running

• Ospedale Regionale di Bellinzona
  Bellinzona, Switzerland Recruiting
• Inselspital - Universitätsspital Bern
  Bern, Switzerland Recruiting
• University Hospital
  Geneva, Switzerland Recruiting
• Centre Hospitalier Universitaire Vaudois
  Lausanne, Switzerland Recruiting
• Gruppo Ospedaliero Moncucco
  Lugano, Switzerland Recruiting
• Kantonsspital St.Gallen
  Sankt Gallen, Switzerland Recruiting

Study contacts

• Principal investigator: Alessandro Casini — University Hospitals of Geneva
• Study coordinator: Alessandro Casini
• Email: alessandro.casini@hcuge.ch
• Phone: 0041223729757

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• ATHNdataset registry for people with bleeding and clotting disorders

  This registry collects health, treatment, and patient-reported information from people with bleeding and clotting disorders seen at ATHN-affiliated centers to help improve care and outcomes.

  Recruiting American Thrombosis and Hemostasis Network · Hickory, North Carolina · NCT06820515

• Managing heavy menstrual bleeding in adolescents with hormonal treatments

  This study is testing how well hormonal treatments can help teenagers with heavy menstrual bleeding, whether or not they have bleeding disorders.

  Recruiting University Hospital, Geneva · Geneva · NCT06740929

• Early genomic testing to find inherited causes of bleeding

  This project will test whether doing genomic testing early helps people referred to hematology with suspected inherited bleeding disorders get diagnosed sooner and more often.

  Recruiting at 2 sites Early Phase 1 Queen's University · Kingston, Ontario and 2 other locations · NCT06736158

• Observational study of blood clotting and bleeding disorders in Chinese patients

  This study looks at blood clotting and bleeding problems in Chinese patients to see how common they are and what factors might affect them.

  Recruiting Peking University People's Hospital · Beijing, Beijing Municipality and 4 other locations · NCT06727669

• Platform for Rare Blood Disorders in Europe

  This study is trying to gather and share information about rare blood disorders across Europe to help researchers understand these conditions better and improve treatment options for patients.

  Recruiting Hospital Universitari Vall d'Hebron Research Institute · Barcelona, Catalonia · NCT06250595

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.