Identifying Causes and Risk Factors for Out-of-Hospital Cardiac Arrest

Cardiac Arrest Pursuit Trial With Unique Registration and Epidemiologic Surveillance

This study is trying to find out what causes out-of-hospital cardiac arrests and what risk factors are involved by comparing patients who had an arrest with people from the community to help improve treatment and outcomes.

Quick facts

• Study type: Observational
• Enrollment: 5340 (estimated)
• Ages: 19 Years to 79 Years
• Sex: All
• Sponsor: Seoul National University Hospital (Academic / other)
• Locations: 1 site (Seoul)
• Trial ID: NCT03700203 on ClinicalTrials.gov

What this trial studies

This observational study aims to identify the causes and risk factors associated with out-of-hospital cardiac arrest (OHCA) by developing a prediction model and novel biomarkers. Conducted across 14 tertiary teaching hospitals in Korea, the study will involve a multicenter case-control design, recruiting 1,780 OHCA patients and 3,560 matched community controls. Data will be collected from emergency departments and health screening centers, with follow-up assessments conducted for survivors at 1, 6, and 12 months post-discharge. The goal is to enhance understanding of OHCA incidence and improve patient outcomes through targeted interventions.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 19 to 79 who have experienced an out-of-hospital cardiac arrest and received emergency medical services.

Not a fit: Patients with cardiac arrest due to trauma, poisoning, or other external causes, as well as those with terminal conditions, may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved prediction and prevention strategies for out-of-hospital cardiac arrest, potentially saving lives.

How similar studies have performed: While similar studies have explored cardiac arrest risk factors, this approach of combining prediction modeling with biomarker development is relatively novel.

Eligibility criteria

Inclusion Criteria:

* 19 to 79 years old
* Out-of-hospital-cardiac arrest providing resuscitation at the site and visiting the emergency department of the participating hospital or transporting from another hospital emergency room (EMS-treated OHCA)
* The cardiac arrest event must not have been predicted for 24 hours before the incident

Exclusion Criteria:

* People who do not consent to personal information and blood supply for research
* Trauma, submersion, poisoning, hanging, suffocation, or other causes of external causes directly contribute to the cardiac arrest
* Patients with a terminal condition known to have no further treatment plans due to malignancy, neurological disease, respiratory disease, rheumatic disease, hematologic disease, renal disease or infectious disease. The terminal condition had to be checked by a doctor or recorded in medical records.
* "Do not have a resuscitation" card or record issued by a doctor.
* Hospice setting at the time of acute cardiac arrest for terminal illness or other reasons.
* pregnant patient
* With a family cannot provide information about patient
* Without a family
* Patients who were transported after admission at the other hospital
* Foreign patients

Where this trial is running

Seoul

• Seoul National University Hospital — Seoul, South Korea (Recruiting)

Study contacts

• Study coordinator: Jeong Ho Park

Conditions Cardiac Arrest, Out-Of-Hospital; Cardiac Arrest