Identifying brain biomarkers for cognitive rehabilitation in schizophrenia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to develop brain-based tools to identify Veterans with schizophrenia who are most likely to benefit from cognitive rehabilitation therapies. It involves comprehensive neurophysiological, clinical, cognitive, and functional assessments of Veterans diagnosed with schizophrenia and healthy controls at the VA San Diego Healthcare System. The study is conducted in two phases: the first phase focuses on optimizing neurophysiological biomarkers linked to brain function, while the second phase evaluates these biomarkers' sensitivity to cognitive training interventions. The ultimate goal is to enhance the effectiveness of cognitive remediation for improving daily functioning in Veterans with chronic psychosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Have a DSM-5 diagnosis of a chronic psychotic disorder (e.g., schizophrenia, schizoaffective disorder, or delusional disorder); or b) are in good general mental and physical health (i.e., no active mental health condition).
2. Fluent in spoken and written English.
3. No impairment in hearing or vision.

Exclusion Criteria:

1. Active substance other than cannabis within the last 30 days as determined by self-report or positive urine toxicology (obtained as part of the screening process).
2. History of significant medical or neurological illness or intellectual disability.
3. Inability to comprehend or provide informed consent.
4. Specific to healthy comparison subjects: past or present diagnosis of schizophrenia, schizoaffective disorder, or other chronic psychotic disorder.

Where it's running

• VA San Diego Healthcare System, San Diego, CA
  San Diego, California, United States Recruiting

Study contacts

• Principal investigator: Juan Molina, MD — VA San Diego Healthcare System, San Diego, CA
• Study coordinator: Juan Molina, MD
• Email: Juan.Molina@va.gov
• Phone: (202) 555-8975

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.