Identifying brain and inflammation markers in older adults at risk of dementia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to identify neuroinflammation and neuroimaging biomarkers in older adults with Mild Cognitive Impairment (MCI) and Subjective Cognitive Decline (SCD) using data-driven artificial intelligence techniques. By analyzing brain structure, cerebral blood flow, and immune cell populations, the study seeks to characterize subgroups at high risk for dementia. Participants will undergo cognitive assessments and MR imaging at various intervals, and blood samples will be collected to evaluate inflammatory markers. The ultimate goal is to develop tailored early interventions for those showing cognitive decline.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* age between 65 and 89 years; 5 years of schooling;
* diagnosis of Mild Cognitive Impairment (Croisile et al., 2011) or
* diagnosis of Subjective Cognitive Decline (Jessen et al., 2014).

Exclusion Criteria:

* neurological pathologies; dementia;
* psychiatric disorders;
* pathologies or orthopedic problems limiting participation to the aerobic physical training program and to the MR imaging.

Where it's running

• Azienda Ospedaliera Universitaria Pisana
  Pisa, Italy Recruiting

Study contacts

• Study coordinator: Paolo Bosco Bosco, PhD
• Email: paolo.bosco@fsm.unipi.it
• Phone: +39 050886180

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.