Identifying biomarkers for retinitis pigmentosa severity
Biomarkers for Prognosis in Different Forms of Retinitis Pigmentosa
This study is trying to find signs in the eye that show how severe retinitis pigmentosa is by looking at the thickness of a specific layer in the retina in people who have the condition.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 35 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS Academic / other |
| Locations | 1 site (Roma) |
| Trial ID | NCT06306690 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify biomarkers that correlate the severity of retinitis pigmentosa with the thickness of the retinal pigment epithelium. Patients with genetically confirmed retinitis pigmentosa will undergo a series of comprehensive ophthalmological examinations, including high-resolution imaging and electroretinography. The study will utilize advanced imaging techniques such as HD-OCT and OCT angiography to evaluate the condition of the retina and assess the potential role of the retinal pigment epithelium in disease progression.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older with genetically confirmed retinitis pigmentosa.
Not a fit: Patients with other retinal diseases or significant visual impairment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide valuable prognostic indicators for patients with retinitis pigmentosa, aiding in the management and treatment of the condition.
How similar studies have performed: While there have been studies focusing on biomarkers in retinal diseases, this specific approach to correlating RPE thickness with RP severity is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who are able to read and sign informed consent * Patients with Retinitis pigmentosa confirmed by genetic test. * Patients older than or equal to 18 years of age Exclusion Criteria: * Other retinal diseases such as macular hole, retinal detachment, macular neovascularization. * Corneal surgery in the last 12 months * Glaucoma with pressure above 25 mmHg in the last three months. * Best Correct Visual Acuity below 1/10 in at least one eye.
Where this trial is running
Roma
- Maria Cristina Savastano — Roma, Italy (Recruiting)
Study contacts
- Study coordinator: Stanislao Rizzo, MD, Prof
- Email: stanislao.rizzo@policlinicogemelli.it
- Phone: 0630151
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.