Identifying and treating heart rhythm issues in patients with specific heart conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of catheter ablation in identifying and eliminating arrhythmogenic substrates to prevent recurrent ventricular arrhythmias and sudden cardiac death in patients with primary cardiomyopathy and/or channelopathies who have an implanted ICD. It is a prospective single-center study conducted at the Arrhythmology Department of San Donato Milanese Hospital. Eligible patients will undergo endo-epicardial electroanatomical 3D mapping and radio-frequency ablation, followed by a structured follow-up schedule to monitor their condition and response to treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients affected by cardiomyopathies and/or channellopaties (long QT syndrome and J-wave syndrome) with and without documented family history of BrS;
* Presence of symptoms attributable to VA and/or presenting documented arrhythmic episodes;
* Patients with an ICD already implanted;
* Patients referred to the centre for an electrophysiological study and indication for a potential concomitant radio-frequency catheter ablation (RFA) of ventricular tachycardia (VT) or ventricular fibrillation (VF);
* Age ≥ 18;
* Willingness to attend follow-up examinations;
* Written informed consent for the participation in the trial

Exclusion Criteria:

* Pregnancy or breast-feeding;
* Life expectancy \< 12 months

Where it's running

• IRCCS Policlinico S. Donato
  San Donato Milanese, Milano, Italy Recruiting

Study contacts

• Principal investigator: Carlo Pappone, MD — Chief of Arrhythmology Department
• Study coordinator: Carlo Pappone, MD
• Email: carlo.pappone@af-ablation.org
• Phone: +39 02 52774260

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.