Identifying and Tracking Parkinson's Disease Symptoms Using Remote Monitoring
A Multi-site Longitudinal Cohort Study of Prodromal and Clinical Parkinson'sDisease
This study is testing if using a smartphone app to track movements and symptoms can help people with early signs of Parkinson's Disease and those with related conditions better understand their health over a year.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 295 (estimated) |
| Ages | 40 Years and up |
| Sex | All |
| Sponsor | McGill University Academic / other |
| Locations | 5 sites (Vancouver, British Columbia and 4 other locations) |
| Trial ID | NCT06812702 on ClinicalTrials.gov |
What this trial studies
This observational study aims to determine the effectiveness of remote monitoring in identifying and tracking motor symptoms in patients with prodromal and clinical Parkinson's Disease (PD). Over the course of one year, participants, including those with idiopathic REM Sleep Behavior Disorder, PD patients, and healthy controls, will use a smartphone application to complete daily tests and have their movements monitored. Additionally, participants will undergo neurological exams and imaging procedures such as DaT-SPECT and MRI. The study also seeks to validate a skin biopsy assay for detecting pathological alpha-synuclein, which is associated with PD.
Who should consider this trial
Good fit: Ideal candidates include individuals over 40 years old with idiopathic REM Sleep Behavior Disorder or diagnosed Parkinson's Disease.
Not a fit: Patients with moderate to severe depression or those participating in other interventional studies may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved methods for early detection and monitoring of Parkinson's Disease symptoms.
How similar studies have performed: While remote monitoring in PD is a growing field, this specific approach combining mobile technology and skin biopsy validation is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * signed consent form, male or female over age 40, ability to follow protocol, additional group-specific inclusion criteria Exclusion Criteria: * participation in interventional clinical study within 3 months of screening, moderate to severe depression in judgement of the investigator, any concomitant disease, condition or treatment which may interfer with the conduct of study (determined by investigator), additional group-specific exclusion criteria
Where this trial is running
Vancouver, British Columbia and 4 other locations
- Pacific Parkinson's Research Centre — Vancouver, British Columbia, Canada (Recruiting)
- Centre hospitalier de l'Université de Montréal (CHUM) — Montreal, Quebec, Canada (Recruiting)
- The Neuro — Montreal, Quebec, Canada (Recruiting)
- The Neuro — Montreal, Quebec, Canada (Recruiting)
- Centre de recherche du CHU de Québec-Université Laval (CHUQ) — Québec, Canada (Recruiting)
Study contacts
- Study coordinator: Nisha Pulimood, PhD
- Email: nisha.pulimood@mcgill.ca
- Phone: +1 514-396-2401
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.