Clinical trial Recruiting at 6 sites Observational Ages 18 and up

ICU clinicians' early judgment of six-month recovery after out-of-hospital cardiac arrest

Official title: Validity of ICU Clinician's Appraisal of Proportionality in CPR

Run by University Hospital, Ghent · NCT07026773 · Data updated 2026-11-12

This project will test whether ICU doctors and nurses can, within the first 24 hours after admission, predict a patient's six-month brain recovery and quality of life after an out-of-hospital cardiac arrest.

More Out-Of-Hospital Cardiac Arrest trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment1000 (estimated)
SponsorUniversity Hospital, Ghent
Academic / other
Locations9 sites (Innsbruck and 8 other locations)
StatusRecruiting
StartedMay 18, 2025
Main results expectedDecember 30, 2026
Study endsDecember 30, 2026
Registry record updatedJune 18, 2025
Trial IDNCT07026773 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Patients included are adults treated for out-of-hospital cardiac arrest who are enrolled in the international STEPCARE study and admitted to a participating ICU where their treating clinicians complete the questionnaire.

Probably not a fit

Patients who have in-hospital cardiac arrest, are not enrolled in STEPCARE, or whose outcomes are determined by immediate irreversible injuries are unlikely to benefit from this study's findings.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study asks ICU doctors and nurses who treat patients enrolled in the STEPCARE study to complete a brief questionnaire estimating six-month neurological outcome and quality of life based on clinical assessment during the first 24 hours after admission. Those clinician estimates will be compared to the actual neurological outcomes and patient-reported quality of life recorded by the STEPCARE study. The goal is to determine how well early bedside impressions match later, multimodal outcome data without changing patient care. No interventions are delivered as part of this study; it uses existing STEPCARE patients and clinician assessments at participating hospitals.

Why it matters

Potential benefit: If successful, earlier and more reliable clinician judgments could help align intensive care decisions with likely long-term outcomes, potentially reducing burdensome treatments and focusing resources on patients with better chances of meaningful recovery.

How similar studies have gone: Previous work on early clinician prognostication after cardiac arrest is limited and has produced mixed results, so this direct comparison with STEPCARE outcomes represents a relatively novel, pragmatic approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Doctors and nurses working in the Intensive Care Unit treating patients included in the STEPCARE study (NCT 05564754)

Exclusion Criteria:

* Doctors and nurses who do not have a direct treatment relationship with a patient included in the STEPCARE study

Where it's running

  • Ziekenhuis Oost-Limburg
    Genk, Belgium
    Recruiting
  • Ghent University Hospital
    Ghent, Belgium
    Recruiting
  • Universitätsklinikum Lübeck
    Lübeck, Germany
    Recruiting
  • Policlinico San Martino
    Genova, Italy
    Recruiting
  • Wakefield Hospital
    Wellington, New Zealand
    Recruiting
  • King Abdulaziz Medical City
    Riyadh, Saudi Arabia
    Recruiting
Show 3 more locations
  • Medical University Innsbruck
    Innsbruck, Austria
    Not yet recruiting
  • Helsinki University Central Hospital
    Helsinki, Finland
    Not yet recruiting
  • Zürich University Hospital
    Zurich, Switzerland
    Not yet recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Cardiac Arrest: Using Ultrasound to Find Hidden Blood Flow

    This study tests whether patients who have out-of-hospital cardiac arrest but no pulse still show some blood flow on ultrasound and whether that finding relates to survival.

    Recruiting University of Massachusetts, Worcester · Denver, Colorado and 7 other locations · NCT07897370

  • Low-dose beta-blocker treatment for adults who survived unexplained ventricular fibrillation

    This trial will try low-dose beta-blockers in adults who survived an out-of-hospital cardiac arrest with no clear cause to see if it reduces dangerous heart rhythms and ICD therapies.

    Recruiting Phase 4 Copenhagen University Hospital, Rigshospitalet · Copenhagen, Dr. and 1 other locations · NCT07405229

  • On-scene ECMO for out-of-hospital cardiac arrest in the Moravian-Silesian Region

    This project will try starting ECMO (mechanical heart-lung support) on scene for adults who have a witnessed out-of-hospital cardiac arrest to see if earlier support improves outcomes.

    Recruiting at 2 sites University Hospital Ostrava · Ostrava, Moravian-Silesian Region and 1 other locations · NCT07041086

  • Head‑up, device‑assisted controlled elevation CPR for out‑of‑hospital cardiac arrest

    This registry will track how head‑up, device‑assisted CPR (using an impedance threshold device plus either active compression‑decompression or mechanical compressions) works for adults who experience out‑of‑hospital cardiac arrest.

    Recruiting Hennepin Healthcare Research Institute · Minneapolis, Minnesota · NCT05588024

  • Using Argon for Ventilation After Cardiac Arrest

    This study is testing if using argon gas mixed with oxygen can help protect the brain and heart in people who have just been resuscitated after a cardiac arrest.

    Recruiting at 7 sites Phase 2 Mario Negri Institute for Pharmacological Research · Genova, GE and 8 other locations · NCT05482945

  • Effect of cooling duration on recovery in children after cardiac arrest

    This study is testing if cooling children who are in a coma after a cardiac arrest for longer periods can help them recover better.

    Recruiting at 62 sites University of Michigan · Birmingham, Alabama and 64 other locations · NCT05376267

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.