Hysteroscopy for treating retained products of conception after miscarriage

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of operative hysteroscopy compared to expectant management in women who have experienced a miscarriage and have retained products of conception (RPOC) as confirmed by ultrasound. The study aims to determine which approach leads to a quicker return to pregnancy for women wishing to conceive again. It is a multicenter, randomized controlled trial that will assess not only the time to the next pregnancy but also the quality of life, safety, and cost-effectiveness of both treatment options. Participants will be monitored for complications and the course of any subsequent pregnancies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients after first trimester miscarriage treated non-surgically with sonographic evidence for the presence of RPOC at follow-up visit after 6 weeks (± 1 week) who have an immediate future pregnancy wish and are willing to give informed consent.

Exclusion Criteria:

* Women aged below 18 years
* Women aged over 39 years
* Women not wanting to achieve pregnancy within the first 6 months after non-surgical treatment for miscarriage
* Women with a history of repeated miscarriage defined as 3 or more consecutive pregnancy losses before 20 weeks of pregnancy duration
* Women with untreated and/or untreatable subfertility
* Women presenting with severe uterine bleeding, defined as uterine bleeding that needs acute intervention on medical grounds
* Women presenting with severe abdominal pain, defined as abdominal pain that needs acute intervention on medical grounds
* Women with fever (\> 38.5° Celsius) or sepsis requiring antibiotic treatment. For the definition of 'sepsis' we refer to the Third International Consensus definitions for Sepsis and Septic Shock (Singer 2016)
* Women with a contraindication for (office) operative hysteroscopy
* Women with a failed non-surgical management for miscarriage, as substantiated by the sonographic finding of an intact gestational sac still in situ
* Women with a congenital uterine anomaly
* Known cervical stenosis making safe uterine access impossible
* Visual or pathological (e.g. on biopsy) evidence of malignancy

Where it's running

• Ghent University Hospital
  Ghent, Belgium Recruiting

Study contacts

• Principal investigator: Tjalina Hamerlynck, MD PhD — University Hospital, Ghent
• Study coordinator: Eline Meireson
• Email: eline.meireson@uzgent.be
• Phone: +3293327817

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Drug-assisted expectant care versus surgery for retained products of conception

  This project tests whether trying drug-assisted expectant management and waiting for the right time for surgery in people with retained products of conception reduces intrauterine scarring and better preserves fertility compared with immediate curettage.

  Recruiting The Third Xiangya Hospital of Central South University · Changsha, Hunan · NCT07421895

• Operative hysteroscopy in the operating room versus the outpatient clinic

  This will test whether operative hysteroscopy done in an outpatient clinic works as well as when it's done in the operating room for women treated for fibroids, polyps, or retained products of conception.

  Recruiting Centre Hospitalier Intercommunal Creteil · Créteil · NCT07146659

• Intracervical vasopressin to help hysteroscopic removal of retained pregnancy tissue.

  This test checks whether injecting vasopressin into the cervix during hysteroscopic removal helps women 18–51 have complete removal of retained pregnancy tissue.

  Recruiting Phase 4 Prisma Health-Upstate · Greenville, South Carolina · NCT07102615

• Evaluating conservative management for retained products of conception and enhanced myometrial vascularity

  This study is testing if gentle treatments for people with leftover pregnancy tissue after a miscarriage can help them recover naturally over two menstrual cycles.

  Recruiting Fu Xing Hospital, Capital Medical University · Beijing · NCT06862089

• Using hyaluronic acid gel to prevent adhesions after surgery for retained pregnancy tissue

  This study is testing if a special gel can help prevent complications like infertility after surgery for leftover pregnancy tissue.

  Recruiting Fu Xing Hospital, Capital Medical University · Beijing, Beijing Municipality · NCT05085067

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.