HRS-1780 treatment for people with primary aldosteronism

A Multicenter, Randomized, Double-blind, Parallel, Placebo-controlled Phase II Clinical Study to Evaluate the Efficacy and Safety of HRS-1780 in Participants With Primary Aldosteronism

This randomized, double-blind trial will try HRS-1780 tablets versus placebo in adults with primary aldosteronism to see if the drug helps control blood pressure and is safe.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 60 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Shandong Suncadia Medicine Co., Ltd. (Industry-sponsored)
• Locations: 2 sites (Chongqing, Chongqing Municipality and 1 other locations)
• Trial ID: NCT07470983 on ClinicalTrials.gov

What this trial studies

This multicenter, randomized, double-blind, placebo-parallel-controlled Phase II trial will enroll about 60 adult participants with diagnosed primary aldosteronism at two hospitals in China. Participants will be randomly assigned to receive HRS-1780 tablets or matching placebo and followed through scheduled visits to monitor blood pressure, laboratory markers, and adverse events. Eligible participants are adults (≥18) who are either not taking antihypertensive drugs or are on a stable antihypertensive regimen and who agree to the informed consent and contraception requirements. The trial is designed to collect preliminary efficacy and safety data to inform further development of HRS-1780.

Who should consider this trial

Good fit: Adults aged 18 or older with a confirmed diagnosis of primary aldosteronism who can attend visits at the study hospitals, are either off antihypertensive drugs or on a stable regimen, and agree to the consent and contraception requirements are ideal candidates.

Not a fit: Patients with known secondary causes of hypertension, severe renal impairment (eGFR < 30 mL/min/1.73 m²), or those who have undergone or plan adrenal-related surgery are unlikely to benefit from this trial.

Why it matters

Potential benefit: If successful, HRS-1780 could provide a new oral treatment option that lowers aldosterone-driven blood pressure and reduces reliance on surgery or high-dose mineralocorticoid receptor antagonists.

How similar studies have performed: Existing effective treatments include mineralocorticoid receptor antagonists and adrenal surgery, while novel targeted oral agents for primary aldosteronism like HRS-1780 remain experimental and are still being tested in early-phase trials.

Eligibility criteria

Inclusion Criteria:

1. Male or female, aged ≥ 18 years on the date of signing the informed consent form.
2. Diagnosed with primary aldosteronism.
3. No use of antihypertensive drugs before screening, or stable use of antihypertensive drugs.
4. Voluntarily sign the informed consent form before the trial, fully understand the trial content, procedures, and possible adverse reactions, and be capable and willing to comply with the protocol requirements to complete the study.
5. From the signing of the informed consent form until 4 weeks after the last dose, the participant has no plan for procreation and is willing to adopt the highly effective contraceptive measures specified in the protocol.

Exclusion Criteria:

1. Has known secondary causes of hypertension.
2. Has previously undergone, or plans to undergo during the study period, adrenal-related surgeries, including adrenalectomy, adrenal ablation, etc.
3. Estimated glomerular filtration rate (eGFR) \< 30 mL/min/1.73 m².
4. Has had any malignancy of an organ system within 5 years before screening.
5. Has received any other investigational drug within 90 days or 5 half-lives before screening (whichever is longer).
6. Has a history of blood donation or blood loss ≥ 400 mL within 3 months before screening, or has received a blood transfusion within 2 months.
7. Known or suspected alcohol or narcotic abuse.
8. Women who are pregnant, breastfeeding, planning pregnancy, or of childbearing potential unable to adopt highly effective contraceptive measures; or men unable to adopt highly effective contraceptive measures.
9. Abnormal daily routine.
10. Use of strong inhibitors/inducers of cytochrome P450 3A4 (CYP3A4) within 1 week before randomization.
11. Severe infection, severe trauma, or major or medium-scale surgery within 1 month prior to screening;
12. Stroke, transient ischemic attack, myocardial infarction, symptomatic heart failure (NYHA III-IV), or coronary revascularization within 3 months prior to screening; and/or planned coronary, carotid, or peripheral artery revascularization at the time of screening;
13. Within 6 months prior to the screening period, participants have clinically significant diseases that, in the judgment of the investigator, may interfere with the trial results or pose additional risks to the administration of the study drug, including but not limited to respiratory, digestive, cardiovascular, endocrine, immune, urinary, adrenal (except for the primary disease), hematological, neurological, psychiatric, or other conditions;
14. Presence or suspected presence of depression, bipolar disorder, suicidal tendencies, schizophrenia, or other severe mental disorders; or participants with mental incapacity or language barriers that prevent them from adequately understanding or participating in the trial process;
15. Alanine aminotransferase (ALT) ≥ 3 × upper limit of normal (ULN);
16. Aspartate aminotransferase (AST) ≥ 3 × ULN;
17. In the judgment of the investigator, any condition that may affect participant safety or otherwise interfere with the evaluation of trial results (including medical, psychological, social, or geographical factors).

Where this trial is running

Chongqing, Chongqing Municipality and 1 other locations

• The First Affiliated Hospital of Chongqing Medical University — Chongqing, Chongqing Municipality, China (Recruiting)
• The First Affiliated Hospital of Zhengzhou University — Zhengzhou, Henan, China (Recruiting)

Study contacts

• Study coordinator: Shenhuan Liu

Conditions Primary Aldosteronism