How weight-loss surgery changes blood vessel health and inflammation
Official title: Effects of Bariatric Surgery on Cardiovascular Risk Profile in Relation to Inflammatory Parameters: Endothelial Phenotyping and Analysis of the Cross-talk Between Adipose Tissue and Endothelium
Run by Maria Cecilia Hospital · NCT07131605 · Data updated 2026-11-12
This project will try to see if weight-loss surgery improves blood vessel function and reduces inflammation in adults with obesity.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 85 (estimated) |
| Sponsor | Maria Cecilia Hospital Academic / other |
| Locations | 1 site (Cotignola, Ravenna) |
| Status | Recruiting |
| Started | November 11, 2024 |
| Main results expected | November 11, 2026 |
| Study ends | November 11, 2026 |
| Registry record updated | May 8, 2026 |
| Trial ID | NCT07131605 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults (≥18 years) with BMI ≥30 kg/m² who are scheduled for mini-gastric bypass or sleeve gastrectomy and can attend baseline and 6- and 12-month follow-up visits.
✕Probably not a fit
Patients with active systemic inflammatory diseases, acute or chronic infections, severe anemia or coagulation disorders, moderate to severe chronic kidney disease, or active malignancy are excluded and unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults with obesity scheduled for mini-gastric bypass or sleeve gastrectomy will be enrolled and have blood, stool, urine samples and cardiology exams collected before surgery and at 6 and 12 months after. Researchers will perform endothelial phenotyping and measure inflammatory markers, adipose-derived factors, and gut-microbiome signals to study how fat tissue communicates with blood vessels. The study tracks changes in vascular function over time as patients lose weight. Results aim to map the timing and mechanisms of vascular recovery after substantial weight loss.
Why it matters
Potential benefit: If successful, the project could show that bariatric surgery lowers vascular inflammation and cardiovascular risk and identify blood or tissue markers that predict recovery of vessel function.
How similar studies have gone: Previous studies show bariatric surgery improves weight, metabolic health, and some cardiovascular risk markers, but the detailed timing and mechanisms of endothelial recovery and adipose–endothelium cross-talk remain less well defined.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Adults (≥ 18 years old); Patients with obesity (Body Mass Index ≥ 30 kg/m²); Patients scheduled to undergo bariatric surgery via mini-gastric bypass or sleeve gastrectomy; Patients able to give their consent and to provide signed and dated informed consent for the processing of personal data; Willingness to attend follow-up visits and undergo all assessments required by the study protocol. Exclusion Criteria: Active systemic inflammatory diseases (e.g., chronic inflammatory bowel diseases, chronic rheumatologic diseases); Acute or chronic infections Severe anemia or coagulation disorders; Moderate to severe chronic kidney disease; Active malignancies.
Where it's running
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Maria Cecilia Hospital
Cotignola, Ravenna, Italy Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.