How the timing of resuming sex after a hysterectomy affects sexual function
Official title: Recommended Time to Resume Sexual Activity After Hysterectomy: Impact on Sexual Function (FSFI® Score) and Complication Rate ISHYS Study
Run by University Hospital, Angers · NCT05728281 · Data updated 2026-11-12
This study will test whether advising women to wait a shorter or longer time before resuming sex after a hysterectomy changes their sexual function, measured by the FSFI score, in sexually active adult women treated for benign gynecologic conditions.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 142 (estimated) |
| Sponsor | University Hospital, Angers Government |
| Locations | 1 site (Angers) |
| Status | Recruiting |
| Started | June 5, 2023 |
| Main results expected | October 5, 2027 |
| Study ends | October 5, 2027 |
| Registry record updated | June 26, 2026 |
| Trial ID | NCT05728281 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adult (≥18) Francophone, sexually active women who consent and are scheduled for a total hysterectomy for benign gynecologic conditions (or selected early endometrial cancer not requiring lymph node dissection).
✕Probably not a fit
People who are not sexually active, under 18, non‑Francophone, or those requiring extensive cancer treatment or lymph node dissection are unlikely to benefit from this study's guidance.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a single-center, randomized, prospective superiority trial at the University Hospital of Angers enrolling sexually active adult Francophone women undergoing total hysterectomy for benign indications (some selected early endometrial cancers are allowed). Participants are randomized to two groups that receive different recommended waiting times before resuming sexual relations and complete pre- and post-operative questionnaires including the FSFI® instrument. The primary outcome is change in FSFI score; secondary outcomes include comparison of post-operative complications between groups, adherence to the recommendation, and reasons for not following the recommendation. All surgical approaches (laparoscopy, vaginal, laparotomy) and both conservative and non-conservative procedures are permitted.
Why it matters
Potential benefit: If successful, the study could give clear guidance on when to safely resume sexual activity after hysterectomy to help improve sexual function and reduce uncertainty for patients.
How similar studies have gone: This is a relatively novel question with little prior randomized evidence on optimal timing for resuming sexual activity after hysterectomy.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient ≥ 18 years old, * Francophone, * Sexually active, * Receiving a conservative or non-conservative total hysterectomy for benign pathology\*, * Having signed a consent form. All surgical approaches are considered, laparoscopic approach with laparoscopic or vaginal closure, vaginal approach and laparotomy. \*The indications for the procedure selected for this study include: * Menometrorrhagia, * Fibroids, * Adenomyosis, * Endometriosis, * Pelvic statics disorder, * Cervical dysplasia, * Endometrial cancer not requiring lymph node dissection or additional treatment.
Where it's running
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University Hospital of Angers
Angers, France Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.