How the blood-vessel lining and oxidative stress affect microcirculation in chronic kidney disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a cross-sectional observational study comparing people with hypertensive chronic kidney disease, people with hypertension without kidney damage, and healthy volunteers. Researchers will measure peripheral microcirculatory reactivity with a laser Doppler flow meter and glycocalyx thickness using Glycocheck. They will also analyze blood for soluble glycocalyx markers, oxidative stress and inflammation markers, PBMC findings, and antioxidant capacity. Results will be correlated to determine relationships between functional microvascular tests, glycocalyx status, and circulating markers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* patients with CKD of hypertensive etiology (grades 1-2 and 3-5; eGFR CKD-EPI GFR ≥ 90 ml/min/1.73 m², i.e. \< 60 mL/min/1.73 m2), non-diabetics, non-smokers
* patients with hypertension (according to ESH2023 Guidelines) without kidney damage (eGFR CKD-EPI \>90 mL/min/1.73 m2) non-diabetics, non-smokers
* healthy volunteer subjects as controls

Exclusion Criteria:

* kidney disease of any other etiology except hypertension
* endocrine, autoimmune or inflammatory diseases that could affect kidney function.
* smoking
* diabetes

Where it's running

• Osijek University Hospital
  Osijek, Croatia Recruiting

Study contacts

• Study coordinator: Ines Drenjančević, MD, PhD
• Email: ines.drenjancevic@mefos.hr
• Phone: +385912241406

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.