How taking multiple blood pressure medicines affects blood pressure drops after anesthesia in heart surgery
The Impact of Multiple Antihypertensive Therapy on Post-Induction Hypotension Burden in Cardiac Surgery Patients: A Prospective Observational Cohort Study
Konya City Hospital · NCT07541222
This study will see if taking several blood pressure medicines before elective heart surgery causes bigger drops in blood pressure after anesthesia and increases the need for emergency blood-pressure drugs.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 160 (estimated) |
| Ages | 40 Years and up |
| Sex | All |
| Sponsor | Konya City Hospital (other) |
| Locations | 1 site (Konya) |
| Trial ID | NCT07541222 on ClinicalTrials.gov |
What this trial studies
This is a prospective observational study of adults aged 40–85 with ASA III–IV undergoing elective cardiac surgery at a single center. Investigators will record patients' chronic antihypertensive medications and group them by drug classes and combinations. Hemodynamics will be monitored with invasive arterial pressure during induction, and post-induction hypotension (PIH) burden will be quantified as the area under the curve for MAP <65 mmHg. The total dose of vasoactive drugs (for example, ephedrine) given to maintain pressure will also be recorded to compare effects of different medication combinations.
Who should consider this trial
Good fit: Adults aged 40 years or older scheduled for elective cardiac surgery who have been taking at least one antihypertensive medication regularly for four weeks or more are the ideal candidates.
Not a fit: Patients not on chronic antihypertensive therapy, those needing emergency surgery, or patients with severe organ failure or very low ejection fraction are unlikely to benefit from the study's findings.
Why it matters
Potential benefit: If successful, the findings could help clinicians decide whether to adjust preoperative blood pressure medicines to reduce dangerous blood pressure drops after anesthesia.
How similar studies have performed: Previous observational studies have linked some antihypertensive classes (notably ACE inhibitors and ARBs) to post-induction hypotension, but results are mixed and the impact of multi-drug combinations is less well studied.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients aged 40 years and older * Undergoing elective cardiac surgery (e.g., isolated CABG, isolated valve surgery, or combined CABG+valve surgery via sternotomy) * Regular use of at least one antihypertensive medication for at least 4 weeks prior to the operation date * Voluntary participation and signed informed consent Exclusion Criteria: * Emergency surgery * Preoperative shock or requirement for high-dose inotropic/vasopressor therapy * End-stage liver or kidney failure * Uncontrolled hypertension * Difficult intubation or prolonged induction process * Ejection fraction less than 35%
Where this trial is running
Konya
- University of Health Sciences, Konya City Hospital — Konya, Turkey (Türkiye) (RECRUITING)
Study contacts
- Principal investigator: Mustafa Aydemir, MD — Konya City Hospital
- Study coordinator: Mustafa Aydemir, MD
- Email: drmustafaaydemir02@gmail.com
- Phone: +905378725583
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Hypotension on Induction, Cardiac Surgery, Antihypertensive Agents, Anesthesia, Intravenous, Hemodynamics, Post-induction hypotension, Cardiac surgery, Antihypertensive drugs