How sensory cues during a meal affect energy burn in healthy adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a cross-over exploratory study in 24 healthy volunteers to see if sensory stimulation during a meal increases diet-induced thermogenesis. Participants will receive a meal bolus with sensory exposure and with sensory deprivation (nasogastric tube) in alternating periods, and energy expenditure will be measured by indirect calorimetry along with temperature assessments and ex vivo analyses. The trial aims to understand whether brain-mediated sensory input contributes to weight regulation beyond macronutrient composition. The approach contrasts physiologic stimuli of normal eating against a deconstructed delivery method to isolate sensory effects on metabolism.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* healthy volunteers of any gender
* BMI between 18-25 kg/m2
* age between 18 and 40 years

Exclusion Criteria:

* concomitant medication except for prescription free analgetics (paracetamol, NSAIDs) and oral contraceptives
* clinically significant concomitant disease states (e.g. renal failure, hepatic dysfunction, cardiovascular disease, diabetes mellitus),
* allergy to local anaesthetic or any of the study meal ingredients
* known or suspected non-compliance, drug or alcohol abuse
* smoker / habitual tobacco use
* habitual excessive alcohol consumption
* inability to follow the procedures of the study
* participation in another study with investigational drug within the 30 days preceding and during the present study
* previous enrolment into the current study
* enrolment of the investigator, his/her family members, employees and other dependent persons
* uncontrolled hypo- or hyperthyroidism
* pregnancy or lactation

Where it's running

• University Hospital Basel, Department of Endocrinology
  Basel, Switzerland Recruiting

Study contacts

• Principal investigator: Sophia J Wiedemann, Dr. phil. Dr. med. M.Sc. — University Hospital, Basel, Switzerland
• Study coordinator: Matthias Betz, Prof.
• Email: Matthias.Betz@usb.ch
• Phone: 0041 61 556 56 54

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.